| Are infertility treatments a potential risk factor for cancer development? Perspective of 30 years of follow-up. | |
| | |
MedLine Citation:
|
PMID: 22475084 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of the present study was to evaluate the possible risk for cancer development in infertile women with over 30 years of follow-up. Cancer development was assessed through linkage with the National Cancer Registry updated to 31 December 2005 in a cohort of 2431 women who were treated for infertility at the Sheba Medical Center in Israel during the period 1964-1974 and contributed more than 84,000 women years of follow-up. Standardized incidence ratios (SIR) were calculated between the observed cancer cases and the expected cancer rates in the general population. The mean age at the end of follow-up was 62.7 years. Eighteen cases of ovarian cancer were observed as compared to 18.1 expected (SIR = 1.0; 95% CI = 0.59-1.57). For breast cancer, 153 cases were observed as compared to 131.9 expected (SIR = 1.16; 95% CI = 0.98-1.36), and for endometrial cancer, 30 cases were observed as compared to 17.8 expected cases (SIR = 1.69; 95% CI = 1.14-2.41). No excess risk associated with exposure to gonadotropins was observed. Infertility was found to be associated with significant increased risk for endometrial cancer and borderline increased risk for breast cancer. Ovarian cancer risk was not found to be elevated. No significant excess risk was associated with treatment with ovulation induction. |
| | |
Authors:
|
Liat Lerner-Geva; Lerner-Geva Liat; Jaron Rabinovici; Rabinovici Jaron; Liraz Olmer; Olmer Liraz; Tzvia Blumstein; Blumstein Tzvia; Shlomo Mashiach; Mashiach Shlomo; Bruno Lunenfeld; Lunenfeld Bruno |
Related Documents
:
|
22563104 - Oral insulin secretagogues, insulin, and cancer risk in type 2 diabetes mellitus. 6549104 - Cancer mortality and solvent exposures in the rubber industry. 23264214 - E-cadherin expression is more associated with histopathological type of thyroid cancer ... 488034 - Mortality and cancer morbidity among cadmium-exposed workers. 21231984 - A novel tumor-associated antigen, cell division cycle 45-like can induce cytotoxic t-ly... 2646084 - The application of leukocyte adherence inhibition assay to patients with colorectal can... |
Publication Detail:
|
Type: Journal Article Date: 2012-04-05 |
Journal Detail:
|
Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 28 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-09-14 Completed Date: 2013-01-30 Revised Date: 2013-04-18 |
Medline Journal Info:
|
Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
|
Languages: eng Pagination: 809-14 Citation Subset: IM |
Affiliation:
|
Women and Children's Health Research Unit, Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel. liatl@gertner.health.gov.il |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Breast Neoplasms / complications, epidemiology*, etiology Cohort Studies Endometrial Neoplasms / complications, epidemiology*, etiology Female Fertility Agents, Female / adverse effects* Follow-Up Studies Humans Incidence Infertility, Female / complications, therapy Israel / epidemiology Medical Records Ovarian Neoplasms / complications, epidemiology*, etiology Ovulation Induction / adverse effects Registries Reproductive Techniques, Assisted / adverse effects* Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Fertility Agents, Female |
| Comments/Corrections | |
Erratum In:
|
Gynecol Endocrinol. 2013 Apr;29(4):400 Note: Liat, Lerner-Geva [corrected to Lerner-Geva, Liat]; Jaron, Rabinovici [corrected to Rabinovici, Jaron]; Liraz, Olmer [corrected to Olmer, Liraz]; Tzvia, Blumstein [corrected to Blumstein, Tzvia]; Shlomo, Mashiach [corrected to Mashiach, Shlomo]; Bruno, Lunenfeld [corrected to Lunenfeld, Bruno] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of watchful waiting compared to immediate test ordering instructions on general practitio...
Next Document: Complement dependent cytotoxicity (CDC) in chronic lymphocytic leukemia (CLL): Ofatumumab enhances a...