Document Detail

Are hypertonic hyperoncotic solutions safe for prehospital small-volume resuscitation? Results of a prospective observational study.
MedLine Citation:
PMID:  12501029     Owner:  NLM     Status:  MEDLINE    
RATIONALE: This prospective observational study was designed to shed light on the routine use of a hypertonic hyperoncotic solution for prehospital small-volume resuscitation in trauma patients. Effects on homeostasis and haemodynamics as well as safety were evaluated. METHODS: One hundred patients with haemorrhagic shock were given hypertonic hyperoncotic solution (6% hydroxyethyl starch plus 7.5% sodium chloride) by bolus infusion (approximately 4 ml/kg bodyweight). Blood was taken before small-volume resuscitation and after the patients' arrival in the emergency room and serum electrolytes, haemoglobin, haematocrit, colloid osmotic pressure and white cell counts were determined. Haemodynamic variables were evaluated before small-volume resuscitation, just before transport and on arrival. RESULTS: Serum sodium and serum chloride increased at best moderately between baseline and arrival (7 and 12 mmol/l, medians; P<0.001) with peak increases of 25 mmol/l for serum sodium and 23 mmol/l for serum chloride. Serum potassium and white cell counts showed no more than minor changes. Haematocrit, haemoglobin and colloid osmotic pressure dropped (7%, 2.3 g/dl and 3.8 mmHg, respectively, medians; P<0.001). On arrival oxygen saturation and systolic and diastolic blood pressure had increased (5%, 30 and 20 mmHg, respectively), whereas heart rate had dropped by 15 b.p.m. (medians; P<0.001). Five patients developed heat sensations, restlessness, voiding urge, poor taste and vomiting, which may have been hypertonic hyperoncotic solution-related. CONCLUSION: Per-protocol bolus infusions of hypertonic hyperoncotic solution containing hydroxyethyl starch do not compromise homeostasis clinically and are rarely associated with clinically manifest side-effects. The treatment regimens used (including small-volume resuscitation) provide early and effective haemodynamic control.
Walter Mauritz; Wolfgang Schimetta; Sabine Oberreither; Werner Pölz
Related Documents :
8542489 - Right lung ventilation in a porcine open-chest shock model.
8902949 - Hypertonic saline/dextran treatment for severe pressure-driven hemorrhage in dehydrated...
24968929 - Blood pressure variability on antihypertensive therapy in acute intracerebral hemorrhag...
17901839 - Beneficial effects of recombinant human activated protein c in a ewe model of septic sh...
21125469 - Role of controlled lumbar csf drainage for icp control in aneurysmal sah.
7760409 - Prospective, randomized trial of survivor values of cardiac index, oxygen delivery, and...
8010799 - Autogenous cardiac assist with chronic descending thoracic aortomyoplasty.
8678689 - Effect of triiodothyronine on graft function in a model of heart transplantation.
15520689 - Skeletal and dental changes in the sagittal, vertical, and transverse dimensions after ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of emergency medicine : official journal of the European Society for Emergency Medicine     Volume:  9     ISSN:  0969-9546     ISO Abbreviation:  Eur J Emerg Med     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-25     Completed Date:  2003-04-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9442482     Medline TA:  Eur J Emerg Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  315-9     Citation Subset:  IM    
Department of Anaesthesia and Critical Care, Lorenz Böhler Trauma Center, Donaueschingenstrasse 13, A-1200 Vienna, Austria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Emergency Medical Services / methods*
Hetastarch / administration & dosage
Prospective Studies
Resuscitation / methods*
Saline Solution, Hypertonic
Shock, Hemorrhagic / therapy*
Treatment Outcome
Reg. No./Substance:
0/Saline Solution, Hypertonic; 9005-27-0/Hetastarch

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Database deconvolution.
Next Document:  Epidemiology, treatment and outcome of acidotic, acute, cardiogenic pulmonary oedema presenting to a...