Document Detail

Are hypertensives hypercoagulable?
MedLine Citation:
PMID:  7869410     Owner:  NLM     Status:  MEDLINE    
Angiotensin II is a prothrombotic vasoconstrictor. This study proves that many hypertensives are hypercoagulable and at risk for myocardial infarction. The modified recalcification time (MRT) test, used to assess hypercoagulability, incorporates the role of tissue factor in coagulation by activating the monocyte with endotoxin to release latent tissue factor. Aliquots of citrated blood obtained from hypertensives and normotensive controls were placed in two groups of vials, one with saline (group S) and one with endotoxin (group E). All vials were incubated at 37 degrees C for 2 hours, citrate neutralized with calcium chloride, and the MRT (in minutes) for group S (MRT S) and for group E (MRT E) was determined. Mean MRT S values +/- standard deviation (SD) for hypertensives (n = 25) and for controls (n = 27) were 6.4 +/- 1.2 and 6.8 +/- 1.2, respectively. The MRT E values were 4.3 +/- 1.2 and 5.7 +/- 0.9 for the hypertensives and controls, respectively. The MRT E, not the MRT S, was significant. Hypertensives had MRT E values < 4.5 minutes, and by our established criteria, were hypercoagulable. We conclude that because hypercoagulability is a risk factor for thrombosis, hypertensives with short MRT E values may be at increased risk for myocardial or other thrombotic events.
M A Miller; C R Spillert; R Ponnudurai; S Bonthu; E J Lazaro
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the National Medical Association     Volume:  87     ISSN:  0027-9684     ISO Abbreviation:  J Natl Med Assoc     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-03-24     Completed Date:  1995-03-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503090     Medline TA:  J Natl Med Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  71-2     Citation Subset:  IM    
Department of Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark 07103-2757.
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MeSH Terms
Blood Coagulation Tests / methods*
Hypertension / blood*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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