Document Detail

Are hyperlinear palms and dry skin signs of a concomitant autosomal ichthyosis vulgaris in atopic dermatitis?
MedLine Citation:
PMID:  2477977     Owner:  NLM     Status:  MEDLINE    
In 30% to 40% of cases atopic dermatitis (AD) is believed to be associated with autosomal dominant ichthyosis vulgaris (ADI). The diagnosis of ADI can be proved by the ultrastructural demonstration of a defective keratohyalin (KH) synthesis, resulting in minute granules of crumbly appearance in only one layer of granular cells. To investigate the suggested frequent association of ADI with AD, ultrastructural examination of dry skin of 49 AD patients was performed. Only in 2 patients abnormal KH was demonstrated by electron microscopy. 17 patients, including the 2 patients with abnormal KH, showed hyperlinear palms. The present study shows that hyperlinear palms and dry skin are in most cases a phenotypic marker of AD alone and not a sign of concomitant ADI. A histologically one-layered or absent stratum granulosum may occur in the dry skin of patients with only AD and does not indicate a manifestation of concomitant ADI in all cases.
M Fartasch; T L Diepgen; O P Hornstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica. Supplementum     Volume:  144     ISSN:  0365-8341     ISO Abbreviation:  Acta Derm Venereol Suppl (Stockh)     Publication Date:  1989  
Date Detail:
Created Date:  1989-11-22     Completed Date:  1989-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370311     Medline TA:  Acta Derm Venereol Suppl (Stockh)     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  143-5     Citation Subset:  IM    
Department of Dermatology, University of Erlangen, F.R.G.
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MeSH Terms
Dermatitis, Atopic / complications*,  pathology
Foot Dermatoses / pathology
Hand Dermatoses / pathology*
Ichthyosis / complications,  genetics*
Skin / ultrastructure
Skin Diseases / pathology*
Reg. No./Substance:
0/keratohyalin; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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