| Are hyperlinear palms and dry skin signs of a concomitant autosomal ichthyosis vulgaris in atopic dermatitis? | |
| | |
MedLine Citation:
|
PMID: 2477977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In 30% to 40% of cases atopic dermatitis (AD) is believed to be associated with autosomal dominant ichthyosis vulgaris (ADI). The diagnosis of ADI can be proved by the ultrastructural demonstration of a defective keratohyalin (KH) synthesis, resulting in minute granules of crumbly appearance in only one layer of granular cells. To investigate the suggested frequent association of ADI with AD, ultrastructural examination of dry skin of 49 AD patients was performed. Only in 2 patients abnormal KH was demonstrated by electron microscopy. 17 patients, including the 2 patients with abnormal KH, showed hyperlinear palms. The present study shows that hyperlinear palms and dry skin are in most cases a phenotypic marker of AD alone and not a sign of concomitant ADI. A histologically one-layered or absent stratum granulosum may occur in the dry skin of patients with only AD and does not indicate a manifestation of concomitant ADI in all cases. |
| | |
Authors:
|
M Fartasch; T L Diepgen; O P Hornstein |
Related Documents
:
|
7896957 - Actinic damage and skin cancer in albinos in northern tanzania: findings in 164 patient... 20346237 - Adult onset still's disease: clinical presentation in a large cohort of italian patients. 21038547 - Immunohistochemical prognostic criteria in xeroderma pigmentosum. 6630617 - The usefulness of reflectance spectrophotometric measurements during psoralens and ultr... 16615687 - A statistical analysis of factors predisposing patients to heparin resistance. 10795847 - Polyurethane-covered wallstents to recanalize wallstents obstructed by tumor ingrowth f... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta dermato-venereologica. Supplementum Volume: 144 ISSN: 0365-8341 ISO Abbreviation: Acta Derm Venereol Suppl (Stockh) Publication Date: 1989 |
Date Detail:
|
Created Date: 1989-11-22 Completed Date: 1989-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370311 Medline TA: Acta Derm Venereol Suppl (Stockh) Country: SWEDEN |
Other Details:
|
Languages: eng Pagination: 143-5 Citation Subset: IM |
Affiliation:
|
Department of Dermatology, University of Erlangen, F.R.G. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Dermatitis, Atopic / complications*, pathology Female Foot Dermatoses / pathology Hand Dermatoses / pathology* Humans Hyalin Ichthyosis / complications, genetics* Keratins Male Skin / ultrastructure Skin Diseases / pathology* |
| Chemical | |
Reg. No./Substance:
|
0/keratohyalin; 68238-35-7/Keratins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Patch test reactions to inhalant allergens in atopic dermatitis.
Next Document: Histamine and atopic eczema.