| Are high-protein, vegetable-based diets safe for kidney function? A review of the literature. | |
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MedLine Citation:
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PMID: 17383270 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In individuals with chronic kidney disease, high-protein diets have been shown to accelerate renal deterioration, whereas low-protein diets increase the risk of protein malnutrition. Vegetarian diets have been promoted as a way to halt progression of kidney disease while maintaining adequate nutrition. We review the literature to date comparing the effects of animal and vegetable protein on kidney function in health and disease. Diets with conventional amounts of protein, as well as high-protein diets, are reviewed. The literature shows that in short-term clinical trials, animal protein causes dynamic effects on renal function, whereas egg white, dairy, and soy do not. These differences are seen both in diets with conventional amounts of protein and those with high amounts of protein. The long-term effects of animal protein on normal kidney function are not known. Although data on persons with chronic kidney disease are limited, it appears that high intake of animal and vegetable proteins accelerates the underlying disease process not only in physiologic studies but also in short-term interventional trials. The long-term effects of high protein intake on chronic kidney disease are still poorly understood. Several mechanisms have been suggested to explain the different effects of animal and vegetable proteins on normal kidney function, including differences in postprandial circulating hormones, sites of protein metabolism, and interaction with accompanying micronutrients. |
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Authors:
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Adam M Bernstein; Leo Treyzon; Zhaoping Li |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of the American Dietetic Association Volume: 107 ISSN: 0002-8223 ISO Abbreviation: J Am Diet Assoc Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-26 Completed Date: 2007-04-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503061 Medline TA: J Am Diet Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 644-50 Citation Subset: AIM; IM |
Affiliation:
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Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Clinical Trials as Topic Diet, Protein-Restricted* Diet, Vegetarian* Dietary Proteins / administration & dosage* Disease Progression Humans Kidney / drug effects*, physiology Kidney Failure, Chronic / diet therapy* Meat Treatment Outcome Vegetables |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins |
| Comments/Corrections | |
Comment In:
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J Am Diet Assoc. 2007 Oct;107(10):1722; author reply 1722
[PMID:
17904929
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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