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Are high-frequency (600Hz) oscillations in human somatosensory evoked potentials due to phase-resetting phenomena?
MedLine Citation:
PMID:  22632999     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Median nerve somatosensory evoked potentials (SEP) contain a brief oscillatory wavelet burst at about 600Hz (σ-burst) superimposed on the initial cortical component (N20). While invasive single-cell recordings suggested that this burst is generated by increased neuronal spiking activity in area 3b, recent non-invasive scalp recordings could not reveal concomitant single-trial added-activity, suggesting that the SEP burst might instead be generated by phase-reset of ongoing high-frequency EEG. Here, a statistical model and exemplary data are presented reconciling these seemingly contradictory results. METHODS: A statistical model defined the conditions required to detect added-activity in a set of single-trial SEP. Its predictions were tested by analyzing human single-trial scalp SEP recorded with custom-made low-noise amplifiers. RESULTS: The noise level in previous studies did not allow to detect single-trial added-activity in the period concomitant with the trial-averaged σ-burst. In contrast, optimized low-noise recordings do reveal added-activity in a set of single-trials. CONCLUSIONS: The experimental noise level is the decisive factor determining the detectability of added-activity in single-trials. A low-noise experiment provided direct evidence that the SEP σ-burst is at least partly generated by added-activity matching earlier invasive single-cell recordings. SIGNIFICANCE: Quantitative criteria are provided for the feasibility of single-trial detectability of band-limited added-activity.
Authors:
Gunnar Waterstraat; Bartosz Telenczuk; Martin Burghoff; Tommaso Fedele; Hans J Scheer; Gabriel Curio
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-23
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  -     ISSN:  1872-8952     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Neurophysics Group, Department of Neurology, Campus Benjamin Franklin, Charite-University Medicine Berlin, Berlin, Germany.
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