Document Detail

Are gait disturbances and white matter degeneration early indicators of vascular dementia?
MedLine Citation:
PMID:  8087180     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to correlate clinical and brain imaging findings with walking inabilities in patients with possible vascular dementia. For 24 patients with suspected initial vascular dementia according to DSM-III-R, structured neurological, neuropsychological and neuroimaging (magnetic resonance tomography) examinations were evaluated alongside computerized gait analysis. All patients revealed an increased variability of gait lines of various degrees: mild (11%), moderate (32%) and severe (57%). Lateralization of gait patterns was present in 68% and bipedal instabilities of posture in 54%. These findings were significantly correlated with frontal periventricular white matter lesions (WMLs), which probably affect the thalamo-cortico-mediocapsular pathways. The association of gait abnormalities with WMLs of the frontocentral subcortical and periventricular territories in patients with possible vascular dementing illnesses may be used as an early indicator of the disease for follow-up and treatment trials. However, since the degree of gait impairment varies considerably relative to the common mild intellectual limitations, these structural lesions are unlikely to be directly related to the dementing process.
M G Hennerici; M Oster; S Cohen; A Schwartz; L Motsch; M Daffertshofer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Dementia (Basel, Switzerland)     Volume:  5     ISSN:  1013-7424     ISO Abbreviation:  Dementia     Publication Date:    1994 May-Aug
Date Detail:
Created Date:  1994-10-20     Completed Date:  1994-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9010348     Medline TA:  Dementia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  197-202     Citation Subset:  IM    
Department of Neurology, University Heidelberg, Klinikum, Mannheim, FRG.
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MeSH Terms
Aged, 80 and over
Brain / pathology*
Cerebrovascular Disorders / diagnosis,  pathology,  ultrasonography
Dementia, Vascular / diagnosis*,  pathology*,  ultrasonography
Follow-Up Studies
Magnetic Resonance Imaging
Middle Aged
Nerve Degeneration
Prospective Studies
Psychiatric Status Rating Scales
Risk Factors

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