| Are factors at diagnosis of growth hormone deficiency in childhood associated with persistence of growth hormone deficiency into adult life? | |
| | |
MedLine Citation:
|
PMID: 16355807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A proportion of children with growth hormone deficiency (GHD) have persistence of GHD as young adults. To date, no markers have been shown in childhood to have predictive value in determining persistence of GHD into adult life. We examined the hypothesis in 31 patients that variables present at the time of diagnosis of childhood-onset GHD, or those related to the early response to growth hormone (GH) therapy, are associated with the likelihood of persistence of GHD. The results show that, as previously demonstrated, children with GHD are more likely to have persistent severe GHD in adult life when the diagnosis is associated with other pituitary hormone deficiencies (p = 0.02), abnormal pituitary neuroimaging (p = 0.003), induced puberty (p = 0.001), early age of diagnosis (p = 0.03) and lower peak GH response at the first dynamic GH test in childhood (p = 0.02). However, there are no associations of persistent severe GHD with the pattern of pretreatment growth or growth response to GH treatment in the initial phase. |
| | |
Authors:
|
I Banerjee; A Tudorancea; M F Scanlon; J W Gregory |
Related Documents
:
|
8639847 - Quantifiable excess of bone resorption in monoclonal gammopathy is an early symptom of ... 18782877 - Consensus statement on the diagnosis and treatment of children with idiopathic short st... 10968477 - Prediction of height velocity of prepubertal children with growth hormone deficiency in... 1194317 - Stimulation of bone growth by periosteal stripping. a clinical study. 20394507 - Useful parameters of bronchial hyperresponsiveness measured with an impulse oscillation... 18959567 - Obesity in looked after children: is foster care protective from the dangers of obesity? |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of pediatric endocrinology & metabolism : JPEM Volume: 18 ISSN: 0334-018X ISO Abbreviation: J. Pediatr. Endocrinol. Metab. Publication Date: 2005 Oct |
Date Detail:
|
Created Date: 2005-12-16 Completed Date: 2006-01-03 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9508900 Medline TA: J Pediatr Endocrinol Metab Country: England |
Other Details:
|
Languages: eng Pagination: 943-7 Citation Subset: IM |
Affiliation:
|
Department of Child Health, University Hospital of Wales, UK. indi.banerjee@cmmc.nhs.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Child Early Diagnosis Female Forecasting Growth / drug effects Growth Disorders / drug therapy, pathology* Growth Hormone / deficiency* Human Growth Hormone / therapeutic use Humans Hypopituitarism / drug therapy, pathology* Male Prognosis Retrospective Studies Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
12629-01-5/Human Growth Hormone; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Endocrine disorders associated with holoprosencephaly.
Next Document: Response to growth hormone with respect to pubertal status on increased dose in idiopathic growth ho...