Document Detail

Are energy metabolism alterations involved in cardiovascular deconditioning after weightlessness? An hypothesis.
MedLine Citation:
PMID:  11200978     Owner:  NLM     Status:  MEDLINE    
The physiopathogenesis of the cardiovascular deconditioning syndrome observed after actual and simulated microgravity is still under debate, despite numerous studies conducted on the role of blood volume, hormones involved in its regulation, sympathetic nervous system, baroreflexes and venous compliance. Orthostatic intolerance, a reduced exercise capacity and an increased heart rate at rest characterize this syndrome. Recent data suggest, first, the presence of a complex loop between the sympathetic nervous system, carbohydrate metabolism (insulin) and leptin hormone and, second, that this loop, an overall reflection of energy metabolism, participates in cardiovascular regulation. After a resume of studies conducted on fuel homeostasis during actual and simulated microgravity, the possible implications of energy metabolism in the development of the cardiovascular deconditioning syndrome will be discussed.
S Blanc; L Somody; C Gharib
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  441     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-03-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  R39-47     Citation Subset:  IM; S    
Laboratoire de Physiologie de l'Environnement (EA 645), Faculté de Médecine Lyon Grange-Blanche, France.
Space Flight Mission:
Flight Experiment; Skylab Project; long duration; manned
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MeSH Terms
Adaptation, Physiological / physiology
Cardiovascular Physiological Phenomena*
Energy Metabolism / physiology*
Stress, Physiological / physiopathology
Sympathetic Nervous System / physiology
Weightlessness / adverse effects*

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