| Are elevated levels of the tumour marker CA19-9 of any clinical significance?--an evaluation. | |
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MedLine Citation:
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PMID: 10422394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CA 19-9 is a tumour marker which has been used widely in patients with pancreatic adenocarcinoma. Elevated levels are associated with advanced disease at presentation and disease progression during follow-up. CA19-9 levels may also be elevated in a variety of other malignant and benign conditions. This study examined the significance and implications of elevated CA19-9 levels. An analysis of all CA19-9 measurements performed over a 4 yr period was undertaken and 204 patients with elevated CA19-9 levels were identified. One hundred and thirty patients (63.7 per cent) had malignant conditions and 74 (36.3 per cent) had benign conditions or no definite cause was found. There was a significant correlation between CA19-9 levels and CEA (r = 0.3137; P < 0.001) as well as alkaline phosphatase, ALT, AST, bilirubin, gamma glutamyl transpeptidase and lactate dehydrogenase. CA19-9 levels were significantly lower in patients with benign pathology than those with malignant pathology. Similar differences were observed for CEA. CA19-9 levels were in fact highest in patients with pancreatic carcinoma (P < 0.05) while no significant differences were observed for CEA. In conclusion CA19-9 may be elevated in both benign as well as malignant conditions and interpretation of CA19-9 results must be made in light of the clinical condition of the patient. |
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Authors:
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R McLaughlin; D O'Hanlon; M Kerin; P Kenny; H Grimes; H F Given |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Irish journal of medical science Volume: 168 ISSN: 0021-1265 ISO Abbreviation: Ir J Med Sci Publication Date: 1999 Apr-Jun |
Date Detail:
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Created Date: 1999-08-19 Completed Date: 1999-08-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7806864 Medline TA: Ir J Med Sci Country: IRELAND |
Other Details:
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Languages: eng Pagination: 124-6 Citation Subset: IM |
Affiliation:
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Department of General Surgery, University College Hospital, Galway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
/
blood,
diagnosis* Aged CA-19-9 Antigen / blood* Diagnosis, Differential Female Gastrointestinal Neoplasms / blood, diagnosis* Humans Male Middle Aged Pancreatic Neoplasms / blood, diagnosis* Retrospective Studies Sensitivity and Specificity Tumor Markers, Biological / blood* |
| Chemical | |
Reg. No./Substance:
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0/CA-19-9 Antigen; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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