Document Detail

Are elevated levels of the tumour marker CA19-9 of any clinical significance?--an evaluation.
MedLine Citation:
PMID:  10422394     Owner:  NLM     Status:  MEDLINE    
CA 19-9 is a tumour marker which has been used widely in patients with pancreatic adenocarcinoma. Elevated levels are associated with advanced disease at presentation and disease progression during follow-up. CA19-9 levels may also be elevated in a variety of other malignant and benign conditions. This study examined the significance and implications of elevated CA19-9 levels. An analysis of all CA19-9 measurements performed over a 4 yr period was undertaken and 204 patients with elevated CA19-9 levels were identified. One hundred and thirty patients (63.7 per cent) had malignant conditions and 74 (36.3 per cent) had benign conditions or no definite cause was found. There was a significant correlation between CA19-9 levels and CEA (r = 0.3137; P < 0.001) as well as alkaline phosphatase, ALT, AST, bilirubin, gamma glutamyl transpeptidase and lactate dehydrogenase. CA19-9 levels were significantly lower in patients with benign pathology than those with malignant pathology. Similar differences were observed for CEA. CA19-9 levels were in fact highest in patients with pancreatic carcinoma (P < 0.05) while no significant differences were observed for CEA. In conclusion CA19-9 may be elevated in both benign as well as malignant conditions and interpretation of CA19-9 results must be made in light of the clinical condition of the patient.
R McLaughlin; D O'Hanlon; M Kerin; P Kenny; H Grimes; H F Given
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Irish journal of medical science     Volume:  168     ISSN:  0021-1265     ISO Abbreviation:  Ir J Med Sci     Publication Date:    1999 Apr-Jun
Date Detail:
Created Date:  1999-08-19     Completed Date:  1999-08-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806864     Medline TA:  Ir J Med Sci     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  124-6     Citation Subset:  IM    
Department of General Surgery, University College Hospital, Galway.
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MeSH Terms
Adenocarcinoma / blood,  diagnosis*
CA-19-9 Antigen / blood*
Diagnosis, Differential
Gastrointestinal Neoplasms / blood,  diagnosis*
Middle Aged
Pancreatic Neoplasms / blood,  diagnosis*
Retrospective Studies
Sensitivity and Specificity
Tumor Markers, Biological / blood*
Reg. No./Substance:
0/CA-19-9 Antigen; 0/Tumor Markers, Biological

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