Document Detail

Are early life factors responsible for international differences in adult blood pressure? An ecological study.
MedLine Citation:
PMID:  15746202     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although low birthweight has been related to higher mean blood pressure in individuals, there have been very few studies on the contribution of the 'fetal origins hypothesis' to international variations in mean blood pressure. METHODS: Standardized data on mean blood pressure levels in adults aged 20-29 years (available from the INTERSALT study countries) were related to data on mean birthweight and infant mortality rates (IMRs) approximately 25 years earlier (available from the World Health Organization and the United Nations statistics for 24 of these countries). RESULTS: Population mean systolic pressure was inversely correlated with IMR (r = -0.66, P < 0.001) and positively correlated with mean birthweight (r = 0.36, P = 0.108). These correlations were little affected by adjustment either for current body mass index or for current sodium, potassium, and alcohol intake. CONCLUSIONS: The directions of these associations suggest that low mean birthweight and high infant mortality are not important determinants of high population mean adult blood pressure levels.
Christopher G Owen; Peter H Whincup; Derek G Cook
Publication Detail:
Type:  Journal Article     Date:  2005-03-03
Journal Detail:
Title:  International journal of epidemiology     Volume:  34     ISSN:  0300-5771     ISO Abbreviation:  Int J Epidemiol     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-08     Completed Date:  2005-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802871     Medline TA:  Int J Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  649-54     Citation Subset:  IM    
Department of Community Health Sciences, St George's Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK.
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MeSH Terms
Alcohol Drinking / epidemiology
Birth Weight / physiology*
Blood Pressure / physiology*
Body Mass Index
Infant Mortality*
Middle Aged
Potassium / urine
Sodium / urine
Reg. No./Substance:
7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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