Document Detail

Are early human chorionic gonadotropin levels after methotrexate therapy a predictor of response in ectopic pregnancy?
MedLine Citation:
PMID:  20510964     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to evaluate beta-human chorionic gonadotropin (beta-hCG) levels between days 0 and 4 as a predictor of methotrexate therapy success for ectopic pregnancy. STUDY DESIGN: We conducted a retrospective study that evaluated posttreatment beta-hCG levels of 30 patients with ectopic pregnancy who had been treated with single-dose methotrexate therapy. RESULTS: beta-hCG levels decreased between days 0 and 4 in 40.0% of cases, and 100% of these cases had treatment success. beta-hCG levels increased in 60.0% of cases, and 61.8% of these cases had treatment success. In patients with increasing beta-hCG levels on day 4, we calculated the beta-hCG "difference variable" (beta-hCG level at day 4 minus day 0). The median beta-hCG difference variable between cases of treatment success and failure were statistically significant (P = .035). CONCLUSION: beta-hCG level changes between days 0 and 4 after methotrexate therapy have clinical significance and predictive value. Decreasing beta-hCG levels is highly predictive of treatment success. The beta-hCG difference variable is a reliable predictor of success in cases with rising beta-hCG levels after methotrexate therapy.
Quyen Nguyen; Martha Kapitz; Katheryne Downes; Celso Silva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  202     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  630.e1-5     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Mosby, Inc. All rights reserved.
Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, FL, USA.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / therapeutic use
Abortion, Induced / methods
Biological Markers / blood
Chorionic Gonadotropin, beta Subunit, Human / blood*
Methotrexate / therapeutic use*
Patient Selection
Pregnancy, Ectopic / blood,  drug therapy*
Retrospective Studies
Statistics, Nonparametric
Treatment Outcome
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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