Document Detail


Are drug-eluting stents the preferred treatment for multivessel coronary artery disease?
MedLine Citation:
PMID:  16386659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Drug-eluting stents (DES) constitute a major breakthrough in restenosis prevention after initial percutaneous coronary intervention (PCI). Target lesion and vessel revascularization rates of <10% at six months follow-up represent a significant medical advance. Many cardiologists consider it reasonable to assume that PCI using DES ought to be considered equivalent, if not superior, to bypass surgery. The argument made is that in previous randomized clinical trials comparing PCI to coronary artery bypass grafting, restenosis was the determining factor favoring surgery, an event that clinical experience suggests is no longer as frequent. In the absence of a definitive clinical trial to support this view, how should the prudent, cutting edge cardiologist evaluate the data and manage their patients?
Authors:
Lloyd W Klein
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Publication Detail:
Type:  Comment; Journal Article     Date:  2005-12-13
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  47     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-02     Completed Date:  2006-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  22-6     Citation Subset:  AIM; IM    
Affiliation:
Rush Medical College, Chicago, Illinois, USA. lloydklein@comcast.net
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MeSH Terms
Descriptor/Qualifier:
Angioplasty, Transluminal, Percutaneous Coronary*
Coronary Artery Bypass*
Coronary Disease / pathology,  surgery,  therapy*
Coronary Restenosis / prevention & control*
Humans
Paclitaxel / administration & dosage*
Sirolimus / administration & dosage*
Stents*
Chemical
Reg. No./Substance:
33069-62-4/Paclitaxel; 53123-88-9/Sirolimus
Comments/Corrections
Comment On:
J Am Coll Cardiol. 2006 Jan 3;47(1):205-7   [PMID:  16386687 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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