Document Detail


Are dietary choline and betaine intakes determinants of total homocysteine concentration?
MedLine Citation:
PMID:  20219967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Elevated homocysteine concentrations are associated with an increased risk of cardiovascular disease and a decline in cognitive function. Intakes of choline and betaine, as methyl donors, may affect homocysteine concentrations.
OBJECTIVE: The objective was to examine whether choline and betaine intakes, assessed from food-frequency questionnaires, are associated with total plasma homocysteine concentrations under both fasting and post-methionine-load conditions in both pre- and post-folic acid fortification periods in the United States.
DESIGN: We assessed the association between choline and betaine intakes and fasting and post-methionine-load homocysteine concentrations using the US Department of Agriculture revised food-composition tables and evaluated whether the associations varied by folic acid fortification periods in 1325 male and 1407 female participants in the sixth examination (1995-1998) of the Framingham Offspring Study.
RESULTS: A higher choline-plus-betaine intake was associated with lower concentrations of post-methionine-load homocysteine; the multivariate geometric means were 24.1 micromol/L (95% CI: 23.4, 24.9 micromol/L) in the top quintile of intake and 25.0 micromol/L (95% CI: 24.2, 25.7 micromol/L) in the bottom quintile (P for trend = 0.01). We found an inverse association between choline-plus-betaine intake and fasting homocysteine concentrations; the multivariate geometric mean fasting homocysteine concentrations were 9.6 micromol/L (95% CI: 9.3, 9.9 micromol/L) in the top quintile and 10.1 micromol/L (95% CI: 9.8, 10.4 micromol/L) in the bottom quintile (P for trend < 0.001). When we stratified by plasma folate and vitamin B-12 concentrations, the inverse association was limited to participants with low plasma folate or vitamin B-12 concentrations. In the postfortification period, the inverse association between choline-plus-betaine intake and either fasting or post-methionine-load homocysteine was no longer present.
CONCLUSIONS: Choline and betaine intakes were associated with both fasting and post-methionine-load total homocysteine concentrations, especially in participants with low folate and vitamin B-12 status. The inverse association between choline and betaine intakes and homocysteine concentrations was no longer present in the postfortification period.
Authors:
Jung Eun Lee; Paul F Jacques; Lauren Dougherty; Jacob Selhub; Edward Giovannucci; Steven H Zeisel; Eunyoung Cho
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-03-10
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  91     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-05-28     Revised Date:  2014-04-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1303-10     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Betaine / metabolism*
Cardiovascular Diseases / epidemiology
Choline / metabolism*
Cognition Disorders / epidemiology
Diet*
Female
Folic Acid / metabolism,  pharmacology*
Homocysteine / adverse effects,  blood*
Humans
Male
Methionine / metabolism,  pharmacology
Vitamin B 12 / metabolism
Vitamin B 6 / metabolism
Grant Support
ID/Acronym/Agency:
CA125763/CA/NCI NIH HHS; DK55865/DK/NIDDK NIH HHS; DK56350/DK/NIDDK NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS; P30 ES010126/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0LVT1QZ0BA/Homocysteine; 3SCV180C9W/Betaine; 8059-24-3/Vitamin B 6; 935E97BOY8/Folic Acid; AE28F7PNPL/Methionine; N91BDP6H0X/Choline; P6YC3EG204/Vitamin B 12
Comments/Corrections

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