| Are dietary choline and betaine intakes determinants of total homocysteine concentration? | |
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MedLine Citation:
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PMID: 20219967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Elevated homocysteine concentrations are associated with an increased risk of cardiovascular disease and a decline in cognitive function. Intakes of choline and betaine, as methyl donors, may affect homocysteine concentrations. OBJECTIVE: The objective was to examine whether choline and betaine intakes, assessed from food-frequency questionnaires, are associated with total plasma homocysteine concentrations under both fasting and post-methionine-load conditions in both pre- and post-folic acid fortification periods in the United States. DESIGN: We assessed the association between choline and betaine intakes and fasting and post-methionine-load homocysteine concentrations using the US Department of Agriculture revised food-composition tables and evaluated whether the associations varied by folic acid fortification periods in 1325 male and 1407 female participants in the sixth examination (1995-1998) of the Framingham Offspring Study. RESULTS: A higher choline-plus-betaine intake was associated with lower concentrations of post-methionine-load homocysteine; the multivariate geometric means were 24.1 micromol/L (95% CI: 23.4, 24.9 micromol/L) in the top quintile of intake and 25.0 micromol/L (95% CI: 24.2, 25.7 micromol/L) in the bottom quintile (P for trend = 0.01). We found an inverse association between choline-plus-betaine intake and fasting homocysteine concentrations; the multivariate geometric mean fasting homocysteine concentrations were 9.6 micromol/L (95% CI: 9.3, 9.9 micromol/L) in the top quintile and 10.1 micromol/L (95% CI: 9.8, 10.4 micromol/L) in the bottom quintile (P for trend < 0.001). When we stratified by plasma folate and vitamin B-12 concentrations, the inverse association was limited to participants with low plasma folate or vitamin B-12 concentrations. In the postfortification period, the inverse association between choline-plus-betaine intake and either fasting or post-methionine-load homocysteine was no longer present. CONCLUSIONS: Choline and betaine intakes were associated with both fasting and post-methionine-load total homocysteine concentrations, especially in participants with low folate and vitamin B-12 status. The inverse association between choline and betaine intakes and homocysteine concentrations was no longer present in the postfortification period. |
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Authors:
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Jung Eun Lee; Paul F Jacques; Lauren Dougherty; Jacob Selhub; Edward Giovannucci; Steven H Zeisel; Eunyoung Cho |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-03-10 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 91 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-05-28 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1303-10 Citation Subset: AIM; IM |
Affiliation:
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Department of Food and Nutrition, Sookmyung Women's University, Seoul, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Betaine
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metabolism* Cardiovascular Diseases / epidemiology Choline / metabolism* Cognition Disorders / epidemiology Diet* Female Folic Acid / metabolism, pharmacology* Homocysteine / adverse effects, blood* Humans Male Methionine / metabolism, pharmacology Vitamin B 12 / metabolism Vitamin B 6 / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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CA125763/CA/NCI NIH HHS; DK55865/DK/NIDDK NIH HHS; DK56350/DK/NIDDK NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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107-43-7/Betaine; 454-28-4/Homocysteine; 59-30-3/Folic Acid; 62-49-7/Choline; 63-68-3/Methionine; 68-19-9/Vitamin B 12; 8059-24-3/Vitamin B 6 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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