| Are diamond nanoparticles cytotoxic? | |
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MedLine Citation:
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PMID: 17201422 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Finely divided carbon particles, including charcoal, lampblack, and diamond particles, have been used for ornamental and official tattoos since ancient times. With the recent development in nanoscience and nanotechnology, carbon-based nanomaterials (e.g., fullerenes, nanotubes, nanodiamonds) attract a great deal of interest. Owing to their low chemical reactivity and unique physical properties, nanodiamonds could be useful in a variety of biological applications such as carriers for drugs, genes, or proteins; novel imaging techniques; coatings for implantable materials; and biosensors and biomedical nanorobots. Therefore, it is essential to ascertain the possible hazards of nanodiamonds to humans and other biological systems. We have, for the first time, assessed the cytotoxicity of nanodiamonds ranging in size from 2 to 10 nm. Assays of cell viability such as mitochondrial function (MTT) and luminescent ATP production showed that nanodiamonds were not toxic to a variety of cell types. Furthermore, nanodiamonds did not produce significant reactive oxygen species. Cells can grow on nanodiamond-coated substrates without morphological changes compared to controls. These results suggest that nanodiamonds could be ideal for many biological applications in a diverse range of cell types. |
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Authors:
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Amanda M Schrand; Houjin Huang; Cataleya Carlson; John J Schlager; Eiji Omacr Sawa; Saber M Hussain; Liming Dai |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The journal of physical chemistry. B Volume: 111 ISSN: 1520-6106 ISO Abbreviation: J Phys Chem B Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-04 Completed Date: 2007-05-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101157530 Medline TA: J Phys Chem B Country: United States |
Other Details:
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Languages: eng Pagination: 2-7 Citation Subset: IM |
Affiliation:
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Department of Chemical and Materials Engineering, University of Dayton, 300 College Park, Dayton, Ohio 45469-0240, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carbon
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chemistry Cell Line, Tumor Cell Survival Diamond / chemistry* Dose-Response Relationship, Drug Fullerenes / chemistry Humans Metal Nanoparticles / chemistry Microscopy, Electron, Transmission Microscopy, Fluorescence Mitochondria / metabolism Nanoparticles* Nanotubes / chemistry Particle Size Reactive Oxygen Species |
| Chemical | |
Reg. No./Substance:
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0/Fullerenes; 0/Reactive Oxygen Species; 7440-44-0/Carbon; 7782-40-3/Diamond |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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