| Are cotinine assays of value in predicting adverse pregnancy outcome? | |
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MedLine Citation:
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PMID: 10456209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the utility of maternal cotinine concentration as a predictor of preterm and small-for-gestational-age (SGA) deliveries. Subjects were randomly selected from antenatal clinics, and their serum cotinine concentrations at approximately 16 weeks' gestation were compared with self-reports of smoking. The value of these measures in predicting preterm and SGA deliveries was examined, using likelihood ratios and logistic regression, for 845 women with singleton, live births. Smoking status alone (defined by self-report or cotinine) only weakly predicted preterm or SGA delivery. Self-reported moderate/high smoking (top 15% of smokers) had a likelihood ratio (LR) of 2 and a positive predictive value (PPV) of 17%. In contrast, moderate/high cotinine concentration (top 15% of smokers) had an LR of 5 and a PPV of 33%. The predictive value of cotinine was independent of associated maternal characteristics. Cotinine concentration may therefore be a useful predictor of poor pregnancy outcome, and should be considered as a screening tool. |
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Authors:
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F Mathews; R Smith; P Yukdin; A Neil |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of clinical biochemistry Volume: 36 ( Pt 4) ISSN: 0004-5632 ISO Abbreviation: Ann. Clin. Biochem. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-09-22 Completed Date: 1999-09-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0324055 Medline TA: Ann Clin Biochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 468-76 Citation Subset: IM |
Affiliation:
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Division of Public Health and Primary Health Care, University of Oxford, UK. fmathews@ermine.ox.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cotinine
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blood* Female Humans Infant, Newborn Infant, Premature Infant, Small for Gestational Age Likelihood Functions Predictive Value of Tests Pregnancy Pregnancy Outcome* Smoking / blood |
| Chemical | |
Reg. No./Substance:
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486-56-6/Cotinine |
| Comments/Corrections | |
Comment In:
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Ann Clin Biochem. 1999 Nov;36 ( Pt 6):789
[PMID:
10586327
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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