Document Detail


Are colonic regular contractile frequency patterns in slow transit constipation a relevant pathophysiological phenomenon?
MedLine Citation:
PMID:  14567459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pathogenesis of slow transit constipation still remains elusive. Some studies have shown several colonic motor abnormalities; however, it is not easy to understand the relative importance of the single ones. AIMS: Since it has been hypothesized that an excess of periodic distal motor activity may be of pathophysiological importance in patients with slow transit constipation, we evaluated regular colonic contractile frequencies in a homogeneous cohort of these patients. PATIENTS: A total of 26 female patients (age range 34 to 67 years) fulfilling the Rome II criteria for constipation entered the study. No patient had evidence of secondary forms of constipation and distal obstruction. METHODS: Twenty-four hour colonic manometric studies were obtained for each patient. Regular contractile patterns (with frequencies ranging from 2 to 8 cycles/min) were calculated for the entire recording period and in single colonic segments. RESULTS: Overall, regular patterns accounted for about 3% of the total colonic motor activity (average 30 min/day per subject), with the 3 cycles/min being the predominant contractile rhythm. Most of this activity was present in the sigmoid colon, accounting for >50% of the total amount of motility, and it was more prevalent than in the descending and transverse colon; no differences were revealed in the descending with respect to the transverse colon. No daily fluctuations of regular contractile activity, nor a cyclic pattern, nor migration between recording points were observed. CONCLUSIONS: Regular colonic frequency patterns are probably of minor pathophysiological importance in slow transit constipation, even in the light of the scant amount of such phenomena previously documented in healthy subjects.
Authors:
G Bassotti; F Chistolini; E Battaglia; G Chiarioni; F Sietchiping Nzepa; L Dughera; G deRoberto; G Emanuelli; A Morelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  35     ISSN:  1590-8658     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-10-21     Completed Date:  2004-04-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  552-6     Citation Subset:  IM    
Affiliation:
Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, 06131 San Marco (Perugia), Italy. gabassot@tin.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cohort Studies
Colon / physiopathology*
Constipation / physiopathology*
Female
Gastrointestinal Transit / physiology*
Humans
Manometry*
Middle Aged
Monitoring, Physiologic / instrumentation
Muscle Contraction / physiology*
Muscle, Smooth / physiopathology
Postprandial Period / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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