| Are branched chain amino-acids beneficial for nutrition of severe surgical patients with sepsis? | |
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MedLine Citation:
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PMID: 16837267 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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This study investigated in severe sepsis the metabolic effects of two amino acid diets, including the same protein (0.3 gN/kg/day) and caloric intake (2g/kg/day glucose) but with different amino acid composition, 24% branched chain amino-acids (B.C.A.A.) for diet A (8 cases), 41% B.C.A.A. for diet B (11 cases). The two groups were obtained by randomisation at the operative day (D0) and were observed six days (D1-D6). During study, total nitrogen using a Kjeldhal method was measured. At D0 and D6, albumin, total hemolytic complement, transferrin, cholesterol, ammonaemia, insulin and amino acid pattern were studied in blood and skin tests were performed. The data were analysed by Mann-Whitney test. Results: 1) The cumulative nitrogen balances of the six days are not significantly different, but at day 6 in diet B, patients started to be in an anabolic state (+3.7 gN) and in diet A catabolism persisted (-12 gN) (p<0.02). 2) Plasma B.C.A.A. are significantly higher and aromatic acids significantly lower in diet B. In order, Fischer ratio is also significantly different between the two regimens. All the other measured parameters are not significantly different. In this study, the B.C.A.A. enriched diet seems to be beneficial in surgical patients with severe sepsis. |
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Authors:
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M Freysz; B Caillard; J Desgres; C Godbille; G Dupont; H Rombi; M Wilkening |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nutrition (Edinburgh, Scotland) Volume: 8 ISSN: 0261-5614 ISO Abbreviation: Clin Nutr Publication Date: 1989 Apr |
Date Detail:
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Created Date: 2006-07-13 Completed Date: 2008-08-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 61-7 Citation Subset: - |
Affiliation:
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Département d'Anesthésie-Réanimation - Hôpital Général 3, Rue du Faubourg Raines - 21033 Dijon Cédex France. |
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