| Are biochemical parameters of lung maturation from gastric, tracheal, and pharyngeal aspirates comparable? | |
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MedLine Citation:
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PMID: 9618052 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phospholipid parameters -- lecithin/sphingomyelin (L/S) ratio and palmitic acid/stearic acid (P/S) ratio -- of gastric (GA), pharyngeal (PA), and tracheal aspirates (TA) have often been used for estimation of lung maturation. However, it was not known whether values from different sources can be alternatively used. The study was performed to test whether P/S and L/S ratios in GA, PA, and TA are comparable. 11 GA, 30 PA, and 10 TA were obtained from infants within 10 min after birth. All infants were healthy, vaginally delivered with no respiratory distress, and had a gestational age > or = 34 weeks. Patterns of fatty acids were determined by gas chromatography and the L/S ratio by high-performance liquid chromatography. We found lower L/S ratios in GA (16.5 +/- 5.2) when compared with PA(39 +/- 16) or TA (41 +/- 15; p < 0.01); there were no differences between PA and TA. The P/S ratio was in the same range in PA and TA, but lower in GA. As compared with TA and PA, in GA the relative percentage of palmitic acid of all fatty acids was lower, the percentage of monounsaturated fatty acids, however, higher. We conclude that phospholipid parameters of lung maturation in PA and TA, but not in GA, can be alternatively used. |
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Authors:
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M Rüdiger; R Haupt; B Rüstow; R R Wauer |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biology of the neonate Volume: 73 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 1998 |
Date Detail:
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Created Date: 1999-01-12 Completed Date: 1999-01-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 356-61 Citation Subset: IM |
Affiliation:
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Department of Neonatology, Charité/Humboldt University, Berlin, Germany. ruediger@rz.charite.hu-berlin.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Gastric Juice
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chemistry*,
secretion Humans Infant Lung / chemistry*, growth & development* Palmitic Acid / analysis Pharynx / chemistry*, secretion Phosphatidylcholines / analysis Plasmalogens / analysis Prospective Studies Sphingomyelins / analysis Stearic Acids / analysis Trachea / chemistry*, secretion |
| Chemical | |
Reg. No./Substance:
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0/Phosphatidylcholines; 0/Plasmalogens; 0/Sphingomyelins; 0/Stearic Acids; 57-10-3/Palmitic Acid; 57-11-4/stearic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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