Document Detail


Are biochemical parameters of lung maturation from gastric, tracheal, and pharyngeal aspirates comparable?
MedLine Citation:
PMID:  9618052     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phospholipid parameters -- lecithin/sphingomyelin (L/S) ratio and palmitic acid/stearic acid (P/S) ratio -- of gastric (GA), pharyngeal (PA), and tracheal aspirates (TA) have often been used for estimation of lung maturation. However, it was not known whether values from different sources can be alternatively used. The study was performed to test whether P/S and L/S ratios in GA, PA, and TA are comparable. 11 GA, 30 PA, and 10 TA were obtained from infants within 10 min after birth. All infants were healthy, vaginally delivered with no respiratory distress, and had a gestational age > or = 34 weeks. Patterns of fatty acids were determined by gas chromatography and the L/S ratio by high-performance liquid chromatography. We found lower L/S ratios in GA (16.5 +/- 5.2) when compared with PA(39 +/- 16) or TA (41 +/- 15; p < 0.01); there were no differences between PA and TA. The P/S ratio was in the same range in PA and TA, but lower in GA. As compared with TA and PA, in GA the relative percentage of palmitic acid of all fatty acids was lower, the percentage of monounsaturated fatty acids, however, higher. We conclude that phospholipid parameters of lung maturation in PA and TA, but not in GA, can be alternatively used.
Authors:
M Rüdiger; R Haupt; B Rüstow; R R Wauer
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of the neonate     Volume:  73     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1998  
Date Detail:
Created Date:  1999-01-12     Completed Date:  1999-01-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  356-61     Citation Subset:  IM    
Affiliation:
Department of Neonatology, Charité/Humboldt University, Berlin, Germany. ruediger@rz.charite.hu-berlin.de
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MeSH Terms
Descriptor/Qualifier:
Gastric Juice / chemistry*,  secretion
Humans
Infant
Lung / chemistry*,  growth & development*
Palmitic Acid / analysis
Pharynx / chemistry*,  secretion
Phosphatidylcholines / analysis
Plasmalogens / analysis
Prospective Studies
Sphingomyelins / analysis
Stearic Acids / analysis
Trachea / chemistry*,  secretion
Chemical
Reg. No./Substance:
0/Phosphatidylcholines; 0/Plasmalogens; 0/Sphingomyelins; 0/Stearic Acids; 57-10-3/Palmitic Acid; 57-11-4/stearic acid

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