Document Detail


Are azole fungicides a teratogenic risk for human conceptus?
MedLine Citation:
PMID:  20633616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Azole fungicides are widely used in agriculture and in human mycosis. Their antifungal activity is based on their ability to inhibit CYP51, a key enzyme in the formation of fungal wall. Several azole fungicides tested in laboratory animals have been found to possess a common teratogenic potential to induce facial, axial skeleton, and limb defects. The mechanism of the teratogenic effect has been hypothesized to be related to the capability of these substances to alter embryonic retinoic acid catabolism. Although a number of human epidemiological studies were unable to demonstrate a definite relationship between azole exposure during pregnancy and birth defects, some case reports indicate a possible teratogenic effect of high doses of azoles in humans. Because of their common mechanism of action, azole fungicides should be regarded with caution for use in pregnant women.
Authors:
E Giavini; E Menegola
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-07-13
Journal Detail:
Title:  Toxicology letters     Volume:  198     ISSN:  1879-3169     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-24     Completed Date:  2010-09-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  106-11     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Università degli studi di Milano, Dipartimento di Biologia, Via Celoria, 26, I-20133 Milano, Italy. erminio.giavini@unimi.it
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced* / epidemiology,  etiology,  metabolism
Animals
Antifungal Agents / pharmacology,  toxicity*
Embryonic Development / drug effects
Female
Humans
Imidazoles / pharmacology,  toxicity*
Pregnancy
Teratogens / pharmacology,  toxicity*
Tretinoin / metabolism
Triazoles / pharmacology,  toxicity*
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Imidazoles; 0/Teratogens; 0/Triazoles; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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