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Are arterial blood gases necessary in the evaluation of acutely dyspneic patients?
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PMID:  21892979     Owner:  NLM     Status:  MEDLINE    
Arterial blood gases (ABG) are obtained commonly in dyspneic persons presenting to emergency departments. The study by Burri and colleagues found that the information contained in ABG fails to distinguish between pulmonary and other causes of dyspnea. On the other hand, arterial pH was highly predictive of ICU admission and outcome. Until large clinical studies show equivalence between peripheral venous and ABG, we will continue to advocate the use of ABG in the evaluation of acute dyspnea.
Christopher Junker; Guillermo Gutierrez
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Publication Detail:
Type:  Comment; Journal Article     Date:  2011-08-02
Journal Detail:
Title:  Critical care (London, England)     Volume:  15     ISSN:  1466-609X     ISO Abbreviation:  Crit Care     Publication Date:  2011  
Date Detail:
Created Date:  2011-12-06     Completed Date:  2012-08-21     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9801902     Medline TA:  Crit Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  176     Citation Subset:  IM    
Department of Anesthesiology and Critical Care Medicine, The George Washington University MFA, 2150 Pennsylvania Ave, NW, Washington, DC 20037, USA.
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MeSH Terms
Dyspnea / blood*,  diagnosis*
Emergency Service, Hospital*
Comment On:
Crit Care. 2011;15(3):R145   [PMID:  21663600 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Crit Care
Journal ID (iso-abbrev): Crit Care
ISSN: 1364-8535
ISSN: 1466-609X
Publisher: BioMed Central
Article Information
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Copyright ©2011 BioMed Central Ltd
Print publication date: Year: 2011
Electronic publication date: Day: 2 Month: 8 Year: 2011
pmc-release publication date: Day: 2 Month: 8 Year: 2012
Volume: 15 Issue: 4
First Page: 176 Last Page: 176
ID: 3387586
Publisher Id: cc10279
PubMed Id: 21892979
DOI: 10.1186/cc10279

Are arterial blood gases necessary in the evaluation of acutely dyspneic patients?
Christopher Junker1 Email:
Guillermo Gutierrez2 Email:
1Department of Anesthesiology and Critical Care Medicine, The George Washington University MFA, 2150 Pennsylvania Ave, NW, Washington, DC 20037, USA
2Department of Medicine and Anesthesiology, Division of Pulmonary and Critical Care Medicine, The George Washington University MFA, 2150 Pennsylvania Ave, NW, Washington, DC 20037, USA

The recent study by Burri and colleagues examined the usefulness of arterial blood gases (ABG) in the diagnosis and prognosis of 530 dyspneic patients with ABG drawn upon presentation to the emergency department [1]. The study was a retrospective analysis of prospectively collected data performed at a single center. They concluded that ABG cannot be used to distinguish between pulmonary and other causes of dyspnea.

Prior to the introduction of automated blood gas analyzers, blood PO2 and PCO2 could be obtained only by laborious and often inaccurate laboratory methods, such as gas tonometry and Van Slyke manometric extraction of plasma total carbon dioxide. Improvements in electrode technology came with the development of the Astrup pH electrode [2], the Stow/Severinghaus-type PCO2 electrode [3,4] and the polarographic oxygen Clark electrode [5]. Although pulse oximetry has largely superseded the use of arterial PO2 (PaO2), the ease by which ABG can now be measured has made this test de rigueur in the workup of dyspneic patients.

We agree with Burri and colleagues in that PaO2 values serve mainly to triage and to guide treatment, rather than to differentiate among the causes of dyspnea. Except for anxiety hyperventilation, it is difficult to rely solely on ABG to identify a specific clinical syndrome. This is not new information. The poor predictive value of PaO2 in diagnosing patients with pulmonary embolism is well known. In the PIOPED I study of patients with angiographically proven pulmonary embolism and no prior cardiopulmonary disease, 26% had PaO2 >80 mmHg [6]. This figure was 38% in the PIOPED II study (n = 42) [7,8]. The probability of diagnosing an acute pulmonary embolism based on changes in PaO2 did not achieve statistical significance. Further, no combination of PO2 and PCO2 values could reliably exclude pulmonary embolism.

Burri and colleagues also report that arterial pH was a significant predictor of short-term and long-term outcome. Multiple physiological buffers act to preserve the concentration of hydrogen ions in blood within a relatively small range. Decreases in arterial pH are likely to reflect severe impairments or even exhaustion of systemic compensatory mechanisms in patients with acute dyspnea. The predictive value of the arterial pH in dyspneic patients noted by Burri and colleagues supports this hypothesis.

Burri and colleagues propose the use of venous blood pH in the initial evaluation of acute dyspnea, based on data from several single-center studies reporting relatively close limits of agreement (-0.11 to +0.04) between arterial pH and venous blood pH [9,10]. One must keep in mind, however, that muscular activity or regional microcirculatory alterations could result in misleadingly low regional pH values in septic or agitated patients.

Substituting venous blood pH for arterial pH in the evaluation of dyspneic patients is an appealing notion, but one that requires testing in multicenter, prospective clinical studies. Until these studies corroborate the equivalence between arterial and peripheral venous blood gases, or until non-invasive techniques to monitor arterial PCO2 and pH become available, we shall continue to support the use of ABG in the initial evaluation and treatment of patients with acute dyspnea.


ABG: arterial blood gases; ICU: intensive care unit; PaCO2: arterial partial pressure of carbon dioxide; PCO2: partial pressure of carbon dioxide; PO2: partial pressure of oxygen.

Competing interests

The authors declare that they have no competing interests.

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Treger R,Pirouz S,Kamangar N,Corry D,Agreement between central venous and arterial blood gas measurements in the intensive care unitClin J Am Soc NephrolYear: 2010539039410.2215/CJN.0033010920019117

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