| Are analogue insulins superior to human insulin in clinical practice? | |
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MedLine Citation:
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PMID: 20425580 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Insulin analogues were designed to provide more physiologic pharmacokinetic and pharmacodynamic properties compared with human insulin. This article examines the literature over a 2-year period, focusing on studies directly comparing analogue and human insulin in controlled clinical trials and large observational studies documenting the introduction of, or change to, analogue insulin in clinical practice. Findings indicate that analogues provide objective benefits that include improved glycemic control, lower risk of hypoglycemia, lower glucose variability, and (for insulin detemir) reduced weight gain. Recent data with analogues also explore their safety and efficacy in special patient groups such as children and adolescents. These data complement increasing evidence that analogues offer improved acceptability and accessibility to people with diabetes. |
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Authors:
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Jeffrey S Freeman |
Publication Detail:
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Type: Journal Article; Meta-Analysis |
Journal Detail:
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Title: Current diabetes reports Volume: 10 ISSN: 1539-0829 ISO Abbreviation: Curr. Diab. Rep. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101093791 Medline TA: Curr Diab Rep Country: United States |
Other Details:
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Languages: eng Pagination: 176-83 Citation Subset: IM |
Affiliation:
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Division of Endocrinology of the Department of Internal Medicine, Division of Endocrinology and Metabolism, Philadelphia College of Osteopathic Medicine, Suite 324, Philadelphia, PA 19131-1626, USA. jeffreyfreemando@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Clinical Trials as Topic Humans Insulin / analogs & derivatives*, pharmacology* Insulin, Long-Acting / pharmacology Physician's Practice Patterns* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Insulin, Long-Acting; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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