Document Detail

Are age-related deficits in balance performance mediated by time of day in a prosimian primate (Microcebus murinus)?
MedLine Citation:
PMID:  15130679     Owner:  NLM     Status:  MEDLINE    
We examined the effects of age and time of day on balance performance in the gray mouse lemur (Microcebus murinus) in relation to body temperature variations. Groups of young, adult and aged animals were entrained to either short (SP, L/D 10/14) or long photoperiod (LP, L/D 14/10) and tested in the accelerating Rotarod at three phases of their light/dark cycle (beginning and end of the light phase, beginning of the dark phase). In addition, for each test, rectal temperature (Tr) was measured. Under LP, whatever the test phase, this primate showed a clear age-related decrease in balance performance. Under SP, no significant age-related decline in balance could be detected. Whatever the photoperiod, an effect of time of day on balance performance could only be seen in adults, with better performances at the beginning of the dark phase when Tr values were higher. Under LP, daily variations of both balance performance and Tr disappeared with advancing age. Consequently, age differences were substantially greater when testing was conducted during the dark phase of the light/dark cycle. The time of day effect on balance performance and the loss of daily variations with age suggest the influence of age-related changes within the biological clock.
Florence Némoz-Bertholet; Michael Menaker; Fabienne Aujard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental gerontology     Volume:  39     ISSN:  0531-5565     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-07     Completed Date:  2004-10-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  841-8     Citation Subset:  IM    
Département d'Ecologie et de Gestion de la Biodiversité, Muséum National d'Histoire Naturelle, CNRS UMR 5176, 4 avenue du petit château, 91800 Brunoy, France.
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MeSH Terms
Age Factors
Aging / physiology*
Body Temperature / physiology
Postural Balance / physiology*

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