Document Detail

Are women who smoke at higher risk for lung cancer than men who smoke?
MedLine Citation:
PMID:  23425629     Owner:  NLM     Status:  MEDLINE    
Worldwide lung cancer incidence is decreasing or leveling off among men, but rising among women. Sex differences in associations of tobacco carcinogens with lung cancer risk have been hypothesized, but the epidemiologic evidence is conflicting. We tested sex-smoking interaction in association with lung cancer risk within a population-based case-control study, the Environment and Genetics in Lung Cancer Etiology (EAGLE) Study (Lombardy, Italy, 2002-2005). Detailed lifetime smoking histories were collected by personal interview in 2,100 cases with incident lung cancer and 2,120 controls. Odds ratios and 95% confidence intervals for pack-years of cigarette smoking were estimated by logistic regression, adjusted for age, residence area, and time since quitting smoking. To assess sex-smoking interaction, we compared the slopes of odds ratios for logarithm of pack-years in a model for men and women combined. Overall, the slope for pack-years was steeper in men (odds ratio for female-smoking interaction = 0.39, 95% confidence interval: 0.24, 0.62; P < 0.0001); after restriction to ever smokers, the difference in slopes was much smaller (odds ratio for interaction = 0.63, 95% confidence interval: 0.29, 1.37; P = 0.24). Similar results were found by histological type. Results were unchanged when additional confounders were evaluated (e.g., tobacco type, inhalation depth, Fagerström-assessed nicotine dependence). These findings do not support a higher female susceptibility to tobacco-related lung cancer.
Sara De Matteis; Dario Consonni; Angela C Pesatori; Andrew W Bergen; Pier Alberto Bertazzi; Neil E Caporaso; Jay H Lubin; Sholom Wacholder; Maria Teresa Landi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2013-02-20
Journal Detail:
Title:  American journal of epidemiology     Volume:  177     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-02     Completed Date:  2013-05-28     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  601-12     Citation Subset:  IM    
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MeSH Terms
Case-Control Studies
Confounding Factors (Epidemiology)
Lung Neoplasms / chemically induced*,  epidemiology*
Middle Aged
Odds Ratio
Risk Factors
Sex Factors
Smoking / adverse effects*,  epidemiology*
Time Factors
Comment In:
Am J Epidemiol. 2013 Apr 1;177(7):613-6   [PMID:  23425628 ]

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