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Are Twins Growth Restricted?
MedLine Citation:
PMID:  21505376     Owner:  NLM     Status:  Publisher    
It is now well established that intrauterine growth restriction (IUGR) is associated with an increased risk of a range of adult onset diseases, including cardiovascular disease, obesity and type 2 diabetes. Infants from twin pregnancies are generally born smaller than singletons; it therefore has been suggested that twins represent a naturally occurring model of IUGR. Whilst twin gestations contribute significantly to the population burden of preterm birth and small size at birth, whether twins have the same long-term health consequences as IUGR singletons remains unclear. The purpose of this review is to consider what is currently known about the clinical implications of twinning, the differences which exist between the growth and developmental profiles of singleton and twin fetuses, and to use this as a basis for exploring the question of whether fetuses conceived as twins are analogous to IUGR singletons of similar birthweight and gestation. This question is increasingly important in both the clinical and research settings, as the incidence of twinning is increasing and the long-term implications of reduced size at birth are mostly investigated in species which bear multiple offspring. ABBREVIATIONS:
Beverly S Muhlhausler; Serina N Hancock; Frank H Bloomfield; Richard Harding
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-18
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
FOODplus Research Centre, [B.S.M.], The University of Adelaide, SA 5064, Australia; National Research Centre for Growth and Development [S.N.H., F.H.B.], Liggins Institute University of Auckland, Auckland 1142, New Zealand; School of Biomedical Sciences [R.H.], Monash University, Clayton, VIC 3800, Australia.
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