Document Detail

Are there benefits of antihypertensive therapy beyond blood pressure lowering?
MedLine Citation:
PMID:  20978874     Owner:  NLM     Status:  In-Process    
Meta-analyses strongly suggest that the primary preventive benefit of antihypertensive therapy in uncomplicated individuals is the direct result of the lower blood pressure (BP) rather than the choice of agents. In contrast, when comorbidities are present, therapeutic benefit is governed primarily by the appropriateness of the drug class for the comorbidity profile. As progressively lower BP levels are studied, conflicting results and uncertainties continue to emerge. Given the geometric nature of the BP-risk relationship, it is to be expected that benefits will be less dramatic at lower levels of BP. Conflicting results may emerge from intrinsic problems with clinical trials, including uncertainties related to confounded composite end points, interactions of comorbidities, selection bias from the heterogeneous population with hypertension, interindividual response differences, BP variation and measurement artifacts, multiple mechanisms of antihypertensive drugs, and other deficiencies in study design. The mandate for BP reduction remains strong in virtually all clinical situations. Because of clinical heterogeneity, however, no single drug class is preferred in all circumstances.
Joseph L Izzo
Related Documents :
18401224 - The use of olmesartan medoxomil as monotherapy or in combination with other antihyperte...
19285824 - Emergency department control of blood pressure in intracerebral hemorrhage.
2913554 - Normative arm and calf blood pressure values in the newborn.
17380844 - Effects of long-term lercanidipine or hydrochlorothiazide administration on hypertensio...
18993044 - Automatic air-leak compensation in neuromuscular patients: a feasibility study.
12641684 - Effects of halothane and sevoflurane on qt dispersion in paediatric patients.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current hypertension reports     Volume:  12     ISSN:  1534-3111     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  440-7     Citation Subset:  IM    
Erie County Medical Center, State University of New York at Buffalo, 462 Grider Street, Buffalo, NY 14215, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A relook at preventive therapy for tuberculosis in children.
Next Document:  Use of hydroxychloroquine to prevent thrombosis in systemic lupus erythematosus and in antiphospholi...