Document Detail

Are oral medications effective in the management of acute agitation?
MedLine Citation:
PMID:  22541877     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Current expert guidelines recommend treating agitation with oral medications instead of intramuscular medications if possible. Oral medications are sometimes believed to be inappropriate for the emergency department (ED) as they require patient cooperation and may have a slower onset of action. This review examined published literature for the efficacy of oral agents in agitation.
CLINICAL QUESTION: Are oral medications effective at managing acute agitation?
METHODS: Structured review of PubMed of articles in which the first timepoints of evaluation were<24 hours (i.e., the typical timecourse in the ED).
RESULTS: 11 articles included for final analysis. CONCLUSIONS/CLINICAL BOTTOM LINE: Treatment with oral medications is as effective as intramuscular medications in rapidly reducing psychotic agitation in the ED. Their use is thought to pose less risk to both patient and ED staff and is less coercive. There is little to no evidence about the use of oral medications for ED patients with extreme agitation.
Travis I Gault; Siobhan M Gray; Gary M Vilke; Michael P Wilson
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-04-26
Journal Detail:
Title:  The Journal of emergency medicine     Volume:  43     ISSN:  0736-4679     ISO Abbreviation:  J Emerg Med     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  2013-04-22     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8412174     Medline TA:  J Emerg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  854-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
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MeSH Terms
Acute Disease
Administration, Oral
Antipsychotic Agents / administration & dosage*
Benzodiazepines / administration & dosage*
Clinical Trials as Topic
Psychomotor Agitation / drug therapy*
Reg. No./Substance:
0/Antipsychotic Agents; 12794-10-4/Benzodiazepines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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