| Are lipid ratios less susceptible to change with systemic inflammation than individual lipid components in patients with rheumatoid arthritis? | |
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MedLine Citation:
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PMID: 20682616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rheumatoid arthritis (RA) associates with excess cardiovascular risk and there is a need to assess that risk. However, individual lipid levels may be influenced by disease activity and drug use, whereas lipid ratios may be more robust. A cross-sectional cohort of 400 consecutive patients was used to establish factors that influenced individual lipid levels and lipid ratios in RA, using multiple regression models. A further longitudinal cohort of 550 patients with RA was used to confirm these findings, using generalized estimating equations. Cross-sectionally, higher C-reactive protein (CRP) levels correlated with lower levels of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol ([HDL-C] P ≤ .015), whereas lipid ratios did not correlate with CRP. The findings were broadly replicated in the longitudinal data. In summary, the effects of inflammation on individual lipid levels may underestimate lipid-associated cardiovascular disease (CVD) risk in RA, thus lipid ratios may be more appropriate for CVD risk stratification in RA. |
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Authors:
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Tracey E Toms; Vasileios F Panoulas; Karen M J Douglas; Peter Nightingale; Jacqueline P Smith; Helen Griffiths; Naveed Sattar; Deborah P M Symmons; George D Kitas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-03 |
Journal Detail:
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Title: Angiology Volume: 62 ISSN: 1940-1574 ISO Abbreviation: Angiology Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-11 Completed Date: 2011-02-24 Revised Date: 2011-12-01 |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
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Languages: eng Pagination: 167-75 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anti-Inflammatory Agents / therapeutic use Antirheumatic Agents / therapeutic use Arthritis, Rheumatoid / blood*, complications, drug therapy C-Reactive Protein / metabolism Cohort Studies Cross-Sectional Studies Dyslipidemias / blood*, complications, drug therapy Female Humans Lipids / blood* Male Middle Aged Retrospective Studies Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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17682//Arthritis Research UK; 18848//Arthritis Research UK |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Antirheumatic Agents; 0/Lipids; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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