Document Detail


Are the Jarvik artificial ventricles limited by inflow resistance?
MedLine Citation:
PMID:  7271524     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pneumatic total artificial heart has been assumed to be inflow limited. Mock circulation studies on the Jarvik-5 and Jarvik-7 artificial ventricles seemed to support this assumption because a Starling's response comparable to the natural heart was not achieved. Unfortunately, mock circulation studies do not separate the effects of valvular regurgitation from inflow resistance. By using a simple filling tank, filling times were determined for the Jarvik ventricles that were a function of inflow resistance alone. Theoretical maximum cardiac outputs based on these inflow resistance-dependent filling times were then calculated. For filling pressures around 5 mmHg and under modest diastolic vacuum of 5 cm H2O, the Jarvik ventricles yield a theoretical cardiac output as good as the natural heart's. Thus, inflow resistance is not a limiting factor and valvular regurgitation is left as the most likely cause of a less than optimal Starling's response on mock circulation and in vivo.
Authors:
A P Lioi; S D Nielsen; D B Olsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Artificial organs     Volume:  5     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  118-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cardiac Output
Diastole
Heart Rate
Heart Ventricles
Heart, Artificial* / instrumentation
Humans
Rheology*
Grant Support
ID/Acronym/Agency:
HL-24338-02/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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