Document Detail


Are antisperm antibodies really associated with proven chronic inflammatory and infectious diseases of the male reproductive tract?
MedLine Citation:
PMID:  18715698     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: It is debated whether chronic urogenital inflammations and infections may trigger the formation of antisperm antibodies (ASA) in semen. OBJECTIVE: To evaluate the formation of ASA in defined chronic inflammatory and infectious diseases of the male reproductive tract (MRT). DESIGN, SETTING, AND PARTICIPANTS: Three hundred sixty-five patients retrospectively enrolled in a single center were categorized as having National Institutes of Health (NIH) category II chronic prostatitis (n=38), NIH category IIIa chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) (n=59), NIH category IIIb CP/CPPS (n=213), chronic epididymitis (n=34), and chronic urethritis (n=21). Forty-five age-matched men served as controls. MEASUREMENTS: All subjects underwent microbiologic and cytologic analysis for common bacteria, yeasts, and mycoplasma using the four-glass test. Urine samples, ejaculates, and urethral swabs were analyzed with polymerase chain reaction (PCR) for Chlamydia trachomatis and Neisseria gonorrhea. Semen analysis followed World Health Organization (WHO) standards. ASA in seminal plasma were analyzed using the mixed agglutination reaction (MAR) test. RESULTS AND LIMITATIONS: The overall positive detection rate of clinically significant levels (> or = 50% of spermatozoa coated by ASA) of IgG and IgA antibodies was 1.8% and 0.8%, respectively, in the patient group. No clinically significant levels of ASA were detected in the control group, and no statistically significant difference was observed between controls and patients (IgG, p=1.0; IgA, p=1.0). No difference was found between the different inflammatory and infectious diseases and the control group in the detection rate of ASA, even when the cut-point value was lowered to > or = 1% (IgG, p=0.4; IgA, p=0.3). Moreover, in one selected subgroup of patients (n=26) with persistent increased inflammatory parameters (peroxidase-positive leukocytes [PPL] > or = 1 x 10(6)/ml and elastase > or = 230 ng/ml), no significant difference in the levels of ASA was observed compared with the controls (IgG, p=0.1; IgA, p=0.8). CONCLUSION: There is no association between chronic inflammatory or infectious diseases of the MRT and the presence of ASA in semen.
Authors:
Marcelo Marconi; Adrian Pilatz; Florian Wagenlehner; Thorsten Diemer; Wolfgang Weidner
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Publication Detail:
Type:  Journal Article     Date:  2008-08-12
Journal Detail:
Title:  European urology     Volume:  56     ISSN:  1873-7560     ISO Abbreviation:  Eur. Urol.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-12-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7512719     Medline TA:  Eur Urol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  708-15     Citation Subset:  IM    
Affiliation:
Department of Urology and Pediatric Urology, University of Giessen, Giessen, Germany.
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Comment In:
Eur Urol. 2009 Oct;56(4):715   [PMID:  18715701 ]

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