Document Detail

Are 2-week trials sufficient to indicate efficacy?
MedLine Citation:
PMID:  7675988     Owner:  NLM     Status:  MEDLINE    
The belief in delayed antidepressant action has been encouraged by a confusion between the concepts of full response and the appearance of improvement. Conventional trial designs are insufficiently sensitive to detect early significant separation of drug and placebo. Analysis of time to response is a more sensitive measure to detect early differences in improvement and 2-week studies are therefore proposed as a valid method to demonstrate antidepressant efficacy.
S A Montgomery
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Psychopharmacology bulletin     Volume:  31     ISSN:  0048-5764     ISO Abbreviation:  Psychopharmacol Bull     Publication Date:  1995  
Date Detail:
Created Date:  1995-10-17     Completed Date:  1995-10-17     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101123     Medline TA:  Psychopharmacol Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  41-4     Citation Subset:  IM    
Department of Psychiatry, St Mary's Hospital Medical School, London, UK.
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MeSH Terms
Antidepressive Agents / therapeutic use*
Clinical Trials as Topic*
Depressive Disorder / drug therapy*,  psychology
Research Design*
Time Factors
Reg. No./Substance:
0/Antidepressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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