Document Detail


Architecture of tight junctions and principles of molecular composition.
MedLine Citation:
PMID:  25171873     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The tight junction creates an intercellular barrier limiting paracellular movement of solutes and material across epithelia. Currently many proteins have been identified as components of the tight junction and understanding their architectural organization and interactions is critical to understanding the biology of the barrier. In general the architecture can be conceptualized into compartments with the transmembrane barrier proteins (claudins, occludin, JAM-A, etc.), linked to peripheral scaffolding proteins (such as ZO-1, afadin, MAGI1, etc.) which are in turned linked to actin and microtubules through numerous linkers (cingulin, myosins, protein 4.1, etc.). Within this complex network are associated many signaling proteins that affect the barrier and broader cell functions. The PDZ domain is a commonly used motif to specifically link individual junction protein pairs. Here we review some of the key proteins defining the tight junction and general themes of their organization with the perspective that much will be learned about function by characterizing the detailed architecture and subcompartments within the junction.
Authors:
Christina M Van Itallie; James M Anderson
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Publication Detail:
Type:  REVIEW     Date:  2014-8-26
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  -     ISSN:  1096-3634     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ltd.
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