Document Detail


Architecture of the thrombi removed from coronary artery bypass grafts in a patient with acute myocardial infarction.
MedLine Citation:
PMID:  20182769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using scanning electron microscopy we analyzed thrombotic material removed from coronary bypass grafts in a 57-year-old woman with multilevel atherosclerosis presenting with acute myocardial infarction (AMI). A white thrombotic material removed from the marginal branch bypass that contained large amounts of activated platelets displaying pseudopodia clearly visible at a higher magnification with a relatively low amount of fibrin. The other thrombus obtained from the right posterior descendent branch (RPD) bypass showed a highly organized fibrin structure composed of thicker fibers with low amounts of cellular components. Our findings indicate that the thrombus structure is different in AMI patients in whom the infarct-related vessel is vein anastomosis compared to those with a native coronary artery occluded. These findings help explain resistance of such thrombi to fibrinolysis and faster plaque growth related to fibrin accumulation.
Authors:
Grzegorz Marek; Anna Kablak-Ziembicka; Ewa Stepien; Anetta Undas
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  30     ISSN:  1573-742X     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-24     Completed Date:  2011-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  372-4     Citation Subset:  IM    
Affiliation:
Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka Str, 31-202 Krakow, Poland. gmarek@poczta.onet.pl
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MeSH Terms
Descriptor/Qualifier:
Atherosclerosis
Cell Shape
Coronary Artery Bypass / adverse effects*
Female
Fibrin / ultrastructure
Humans
Microscopy, Electron, Scanning
Middle Aged
Myocardial Infarction*
Platelet Activation
Pseudopodia
Thrombosis / pathology*
Chemical
Reg. No./Substance:
9001-31-4/Fibrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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