| Architecture of a native mitral valve thrombus in a patient with hypereosinophilic syndrome. | |
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MedLine Citation:
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PMID: 21053738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 27-year-old male with a six-year history of hypereosinophilic syndrome (HES) presented with a native mitral valve thrombus, despite therapeutic oral anticoagulation. The thrombus was removed, the mitral valve replaced, and subsequent oral anticoagulation maintained at a higher level (INR 3.5). The patient developed two recurrences of mitral valve thrombosis requiring urgent reoperations, and died shortly after the second intervention. A scanning electron microscopy analysis of the native mitral valve thrombus removed during the first cardiac surgery revealed tightly packed thin fibrin strands forming fuzzy irregular structures, with areas of an almost solid fibrin clot. The fibrin networks indicated a heightened thrombin generation, and may account for a diminished susceptibility to intrinsic fibrinolysis. In conclusion, the unfavorably altered compact structure of the fibrin-rich thrombus, which formed despite adequate anticoagulation, might in part explain the recurrent valvular thrombosis. It may also represent a novel prothrombotic mechanism that operates in HES. |
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Authors:
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Marek Zółciński; Aleksandra Matyja-Bednarczyk; Ewa Stepień; Jerzy Sadowski; Anetta Undas |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of heart valve disease Volume: 19 ISSN: 0966-8519 ISO Abbreviation: J. Heart Valve Dis. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-11-08 Completed Date: 2010-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312096 Medline TA: J Heart Valve Dis Country: England |
Other Details:
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Languages: eng Pagination: 596-8 Citation Subset: IM |
Affiliation:
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Institute of Cardiology, Jagiellonian University Medical College, Cracow, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticoagulants / therapeutic use Fatal Outcome Humans Hypereosinophilic Syndrome / complications*, physiopathology Male Microscopy, Electron, Scanning Mitral Valve / pathology*, ultrastructure Thrombosis / etiology*, pathology*, prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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