Document Detail


Archimedes: a trial-validated model of diabetes.
MedLine Citation:
PMID:  14578245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To build a mathematical model of the anatomy, pathophysiology, tests, treatments, and outcomes pertaining to diabetes that could be applied to a wide variety of clinical and administrative problems and that could be validated. RESEARCH DESIGN AND METHODS: We used an object-oriented approach, differential equations, and a construct we call "features." The level of detail and realism was determined by what clinicians considered important, by the need to distinguish clinically relevant variables, and by the level of detail used in the conduct of clinical trials. RESULTS: The model includes the pertinent organ systems, more than 50 continuously interacting biological variables, and the major symptoms, tests, treatments, and outcomes. The level of detail corresponds to that found in general medical textbooks, patient charts, clinical practice guidelines, and designs of clinical trials. The model is continuous in time and represents biological variables continuously. As demonstrated in a companion article, the equations can simulate a variety of clinical trials and reproduce their results with good accuracy. CONCLUSIONS: It is possible to build a mathematical model that replicates the pathophysiology of diabetes at a high level of biological and clinical detail and that can be tested by simulating clinical trials.
Authors:
David M Eddy; Leonard Schlessinger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes care     Volume:  26     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-27     Completed Date:  2004-06-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3093-101     Citation Subset:  IM    
Affiliation:
Kaiser Permanente Southern California, Pasadena, California, USA. eddyaspen@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Blood Glucose / metabolism
Blood Pressure
Clinical Trials as Topic
Computer Simulation
Diabetes Mellitus, Type 1 / diagnosis,  drug therapy,  epidemiology,  physiopathology*
Diabetes Mellitus, Type 2 / diagnosis,  drug therapy,  epidemiology,  physiopathology*
Glucose Tolerance Test
Hemoglobin A, Glycosylated / metabolism
Humans
Hypoglycemic Agents / therapeutic use
Incidence
Models, Biological*
Risk Factors
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents
Comments/Corrections
Comment In:
Diabetes Care. 2003 Nov;26(11):3182-3   [PMID:  14578260 ]
Diabetes Care. 2003 Nov;26(11):3168-71   [PMID:  14578256 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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