| Archaeological skeletons support a northwest European origin for Paget's disease of bone. | |
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MedLine Citation:
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PMID: 20200980 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The strong genetic component in the etiology of Paget's disease of bone (PDB), together with marked geographic variation in its prevalence, with high frequencies in British populations, has led some to suggest that the disease originated in Britain and spread around the world in recent times by the migration and admixture of British populations. This study aims to investigate this hypothesis by studying the world geographic distribution of PDB cases identified in ancient skeletons excavated from archaeological sites. The methodology is a review of PDB cases described in the literature. There were 109 cases that met modern diagnostic criteria. All came from Western Europe, 94% from England. These data support the hypothesis that PDB originated in this geographic region. |
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Authors:
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Simon Mays |
Publication Detail:
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Type: Historical Article; Journal Article |
Journal Detail:
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Title: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Volume: 25 ISSN: 1523-4681 ISO Abbreviation: J. Bone Miner. Res. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-11 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610640 Medline TA: J Bone Miner Res Country: United States |
Other Details:
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Languages: eng Pagination: 1839-41 Citation Subset: IM |
Affiliation:
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Department of Archaeological Sciences, English Heritage, Fort Cumberland, Portsmouth, UK. simon.mays@english-heritage.org.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Archaeology* Europe / epidemiology Femur / pathology, radiography Geography History, Medieval Humans Osteitis Deformans / epidemiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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