Document Detail

Archaeological skeletons support a northwest European origin for Paget's disease of bone.
MedLine Citation:
PMID:  20200980     Owner:  NLM     Status:  MEDLINE    
The strong genetic component in the etiology of Paget's disease of bone (PDB), together with marked geographic variation in its prevalence, with high frequencies in British populations, has led some to suggest that the disease originated in Britain and spread around the world in recent times by the migration and admixture of British populations. This study aims to investigate this hypothesis by studying the world geographic distribution of PDB cases identified in ancient skeletons excavated from archaeological sites. The methodology is a review of PDB cases described in the literature. There were 109 cases that met modern diagnostic criteria. All came from Western Europe, 94% from England. These data support the hypothesis that PDB originated in this geographic region.
Simon Mays
Publication Detail:
Type:  Historical Article; Journal Article    
Journal Detail:
Title:  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research     Volume:  25     ISSN:  1523-4681     ISO Abbreviation:  J. Bone Miner. Res.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-11     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610640     Medline TA:  J Bone Miner Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1839-41     Citation Subset:  IM    
Department of Archaeological Sciences, English Heritage, Fort Cumberland, Portsmouth, UK.
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MeSH Terms
Europe / epidemiology
Femur / pathology,  radiography
History, Medieval
Osteitis Deformans / epidemiology*

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