| Arc of a vicious circle: pathways activated by Mycobacterium tuberculosis that target the HIV-1 LTR. | |
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MedLine Citation:
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PMID: 21852682 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this review, we examine how a subset of signal transduction cascades initiated by Mycobacterium tuberculosis (Mtb) infection modulates transcription mediated by the human immunodeficiency virus type 1 long terminal repeat (HIV-1 LTR). We describe two distinct phases of signaling that target transcription factors known to bind the HIV-1 LTR, and thus drive viral transcription and replication, in cells of the Mtb-infected host. First, Mtb-derived molecules, including cell wall components and DNA, interact with a number of host pattern recognition receptors (PRRs). Second, cytokines and chemokines secreted in response to Mtb infection initiate signal transduction cascades through their cognate receptors. Given the variation in cell wall components among distinct clinical Mtb strains, the initial PRR interaction leading to direct LTR activation and differential cytokine and chemokine production is likely to be an important aspect of Mtb strain-specific regulation of HIV-1 transcription and replication. Improved understanding of these molecular mechanisms in the context of both bacterial and host genetics should provide key insights into the accelerated viral replication and disease progression characteristic of HIV/TB co-infection. |
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Authors:
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James V Falvo; Shahin Ranjbar; Luke D Jasenosky; Anne E Goldfeld |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-18 |
Journal Detail:
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Title: American journal of respiratory cell and molecular biology Volume: - ISSN: 1535-4989 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8917225 Medline TA: Am J Respir Cell Mol Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Program in Cellular and Molecular Medicine, Childrens' Hopsital Boston, Immune Disease Institute/Harvard Medical School, Boston, Massachusetts, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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