| Arbitrarily primed polymerase chain reaction for fingerprinting the genotype identification of mutans streptococci in children with Down syndrome. | |
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MedLine Citation:
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PMID: 15779663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated the possible intrafamilial similarity of mutans streptococcal strains in some families with a child with Down syndrome using chromosomal DNA fingerprinting. The isolates were genotyped using arbitrarily primed polymerase chain reaction with the OPA 02 and OPA 03 primers. The results showed that five children with Down syndrome harbored mutans streptococci genotypes different from those of their mothers. A matching of genotypes was observed within the control pair (mother/child without Down syndrome). After six months, new samples were collected from all participants. Analysis showed that samples from children with Down syndrome were colonized by a new strain of Streptococcus mutans that did not match the previously collected one. The results suggest the S. mutans indigenous bacteria change more than once in children with Down syndrome. |
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Authors:
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Simone Barone; Claudia Macedo; José Moacir Marin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry Volume: 25 ISSN: 0275-1879 ISO Abbreviation: Spec Care Dentist Publication Date: 2005 Jan-Feb |
Date Detail:
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Created Date: 2005-03-22 Completed Date: 2005-04-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8103755 Medline TA: Spec Care Dentist Country: United States |
Other Details:
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Languages: eng Pagination: 37-42 Citation Subset: D |
Affiliation:
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Department of Histology, Dentistry School, Fundação Educacional de Barretos, State University of Sao Paulo, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child DNA Fingerprinting / methods* DNA Primers / diagnostic use* DNA, Bacterial / analysis Down Syndrome / microbiology* Female Follow-Up Studies Genotype Humans Male Mothers Random Amplified Polymorphic DNA Technique / methods* Saliva / microbiology Streptococcus mutans / classification*, genetics Streptococcus sobrinus / classification, genetics |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/DNA, Bacterial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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