| Arachidonic acid-sensitive A-currents and multiple Kv4 transcripts are expressed in chick ciliary ganglion neurons. | |
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MedLine Citation:
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PMID: 9602108 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A-currents (IA) of chick ciliary ganglion (CG) neurons were blocked reversibly by arachidonic acid and a non-metabolizable analog of arachidonic acid, 5,8,11,14-eicosatetraynoic acid. Inhibition of IA by both lipids was observed in whole-cell recordings and in excised inside-out patches, suggesting that Kv4 (Shal) subunits contribute to functional IA channels in CG neurons. Consistent with this, Kv4.2 and Kv4.3 cDNAs were isolated by RT-PCR from chick CG neurons. |
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Authors:
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L Dryer; Z Xu; S E Dryer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 789 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-07-27 Completed Date: 1998-07-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 162-6 Citation Subset: IM |
Affiliation:
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Department of Biology and Biochemistry, University of Houston, TX 77204-5513, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acid / pharmacology* Chick Embryo Electric Conductivity Ganglia, Parasympathetic / cytology, embryology, physiology* Neurons / drug effects, metabolism, physiology* Potassium Channels / genetics* Potassium Channels, Voltage-Gated* RNA, Messenger / metabolism* Shal Potassium Channels |
| Grant Support | |
ID/Acronym/Agency:
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NS-32748/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Potassium Channels; 0/Potassium Channels, Voltage-Gated; 0/RNA, Messenger; 0/Shal Potassium Channels; 506-32-1/Arachidonic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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