| Arachidonic acid products in airway nociceptor activation during acute lung injury. | |
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MedLine Citation:
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PMID: 21622966 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We have reported that airway nociceptors [C fiber receptors (CFRs) and high threshold A-delta fiber receptors (HTARs)] are activated during oleic acid (OA) induced acute lung injury. In the current studies, we tested the hypothesis that this nociceptor activation is mediated by arachidonic acid products. In anesthetized, open chest, and mechanically ventilated rabbits, we examined the response of the nociceptors to intravenous injection of OA before and after blocking the cyclo-oxygenase pathways by indomethacin. Pre-treatment with indomethacin (20 mg/kg) decreased the background activities of both CFRs (from 0.48±0.12 to 0.25±0.08, n=7, p<0.05) and HTARs (from 0.54±0.14 to 0.23±0.08, n=10, p<0.01). It also blocked the nociceptors' response to OA. Similarly, pre-treatment with thromboxane synthase inhibitor (ketoconazole) also blocked the nociceptor response to OA. In addition, local microinjection or intravenous injection of a thromboxane mimetic stimulated CFRs and HTARs. The current results clearly indicate that arachidonic acid metabolites mediate airway nociceptor activation during OA-induced acute lung injury and suggest that thromboxane may be a key mediator. |
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Authors:
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Shuxin Lin; Huafeng Li; Ling Xu; Bogdan Moldoveanu; Juan Guardiola; Jerry Yu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-27 |
Journal Detail:
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Title: Experimental physiology Volume: - ISSN: 1469-445X ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Univ of Louisville; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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