Document Detail

Arachidonic acid and other fatty acids directly activate potassium channels in smooth muscle cells.
MedLine Citation:
PMID:  2471269     Owner:  NLM     Status:  MEDLINE    
Arachidonic acid, as well as fatty acids that are not substrates for cyclooxygenase and lipoxygenase enzymes, activated a specific type of potassium channel in freshly dissociated smooth muscle cells. Activation occurred in excised membrane patches in the absence of calcium and all nucleotides. Therefore signal transduction pathways that require such soluble factors, including the NADPH-dependent cytochrome P450 pathway, do not mediate the response. Thus, fatty acids directly activate potassium channels and so may constitute a class of signal molecules that regulate ion channels.
R W Ordway; J V Walsh; J J Singer
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  244     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-12     Completed Date:  1989-07-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1176-9     Citation Subset:  IM    
Department of Physiology, University of Massachusetts Medical School, Worcester 01655.
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MeSH Terms
Arachidonic Acid
Arachidonic Acids / pharmacology*
Bufo marinus
Fatty Acids, Nonesterified / pharmacology*
Ion Channels / drug effects,  physiology*
Membrane Potentials / drug effects
Muscle, Smooth / physiology*
Stomach / physiology
Grant Support
Reg. No./Substance:
0/Arachidonic Acids; 0/Fatty Acids, Nonesterified; 0/Ion Channels; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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