| Arachidonic acid and other fatty acids directly activate potassium channels in smooth muscle cells. | |
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MedLine Citation:
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PMID: 2471269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arachidonic acid, as well as fatty acids that are not substrates for cyclooxygenase and lipoxygenase enzymes, activated a specific type of potassium channel in freshly dissociated smooth muscle cells. Activation occurred in excised membrane patches in the absence of calcium and all nucleotides. Therefore signal transduction pathways that require such soluble factors, including the NADPH-dependent cytochrome P450 pathway, do not mediate the response. Thus, fatty acids directly activate potassium channels and so may constitute a class of signal molecules that regulate ion channels. |
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Authors:
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R W Ordway; J V Walsh; J J Singer |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 244 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1989 Jun |
Date Detail:
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Created Date: 1989-07-12 Completed Date: 1989-07-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1176-9 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Massachusetts Medical School, Worcester 01655. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acid Arachidonic Acids / pharmacology* Bufo marinus Fatty Acids, Nonesterified / pharmacology* Ion Channels / drug effects, physiology* Kinetics Membrane Potentials / drug effects Muscle, Smooth / physiology* Stomach / physiology |
| Grant Support | |
ID/Acronym/Agency:
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DK-31620/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Fatty Acids, Nonesterified; 0/Ion Channels; 506-32-1/Arachidonic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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