| Arachidonic acid metabolites and their circadian rhythm in patients with allergic bronchial asthma. | |
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MedLine Citation:
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PMID: 3233695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to investigate circadian variation in concentrations of arachidonic acid (AA) metabolites in relation to the circadian pattern in bronchial patency. Blood samples were obtained at 4-hr intervals from 2000 of 1 day until 1400 of the next from 12 diurnally active asthmatic and six diurnally active non-asthmatic patients. Bloods were analyzed for the prostanoids thromboxane A2 (measured as stable metabolite 6-keto-PGF1a), PGE2 and PGF2a. Airways patency was assessed by self-measurement of peak expiratory flow (PEF). In asthmatics, circadian variation was detected in PEF as well as PGE2 and TXB2. The circadian trough of the PEF rhythm closely coincided with the circadian peak of the PGE2 and TXB2 rhythms. In the controls, the PEF was not circadian rhythmic. Of the AA metabolites only 6-keto-PGF1a exhibited 24-hr bioperiodicity in the controls. The controls exhibited a significantly higher circadian mean of PEF (P less than 0.001), while the asthmatics had a lower 24-hr average PGE2 but greater mean TXB2/PGE2 ratio. The obstructive effect caused by the overall 24-hr deficiency of PGE2 in asthmatics is possibly amplified by the increased of TXB2 during the early morning hours. This dissociation of the temporal patterns in TXB2 and PGE2 levels over the 24 hr is discussed as a characteristic finding for asthmatics. |
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Authors:
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G Kunkel; S Nigam; D Herold; L Jusuf; D L Albright |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chronobiology international Volume: 5 ISSN: 0742-0528 ISO Abbreviation: Chronobiol. Int. Publication Date: 1988 |
Date Detail:
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Created Date: 1989-04-28 Completed Date: 1989-04-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8501362 Medline TA: Chronobiol Int Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 387-94 Citation Subset: IM |
Affiliation:
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Department of Clinical Immunology, Klinikum Steglitz, Free University of Berlin, F.R.G. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arachidonic Acids / blood* Asthma / blood*, physiopathology Circadian Rhythm* Dinoprost / blood Dinoprostone / blood Female Humans Male Middle Aged Peak Expiratory Flow Rate Prostaglandins F / blood Reference Values Thromboxane B2 / blood |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Prostaglandins F; 363-24-6/Dinoprostone; 54397-85-2/Thromboxane B2; 551-11-1/Dinoprost; 745-62-0/prostaglandin F1 |
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