| Arachidonic acid metabolites in human nasal polyps. | |
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MedLine Citation:
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PMID: 8383418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arachidonic acid metabolites (AAMs) are known to be involved in inflammation. It is suggested that AAMs play an important role in the pathogenesis of nasal polyp. We have measured the levels of prostaglandin E2, 6-keto prostaglandin F1 alpha, thromboxane B2, leukotriene B4 and a mixture of leukotriene C4, D4 and E4 in both nasal polyp and maxillary sinus mucosa by radioimmunoassay. Our results showed that arachidonic acid metabolism in nasal polyps from allergic patients was more active than that from non-allergic patients. The arachidonic acid metabolism in nasal polyp was more active than in maxillary sinus mucosa among allergic patients. On the other hand, arachidonic acid metabolism in maxillary sinus mucosa was more active than that in nasal polyps among non-allergic patients. On the basis of these results, we hypothesized the causal mechanisms of nasal polyps as follows: The nasal polyp in allergic patients is caused by primary inflammation of the nasal mucosa, and sinusitis occurs secondarily. In non-allergic patients, the primary side of inflammation is located in the maxillary sinus mucosa, leading to the secondary formation of nasal polyp. |
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Authors:
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S Ogino; M Irifune; T Harada; H Kikumori; T Matsunaga |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta oto-laryngologica. Supplementum Volume: 501 ISSN: 0365-5237 ISO Abbreviation: Acta Otolaryngol Suppl Publication Date: 1993 |
Date Detail:
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Created Date: 1993-04-08 Completed Date: 1993-04-08 Revised Date: 2008-02-13 |
Medline Journal Info:
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Nlm Unique ID: 0370355 Medline TA: Acta Otolaryngol Suppl Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 85-7 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, Osaka University Medical School, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha
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analysis Adolescent Adult Arachidonic Acids / analysis*, metabolism Child Dinoprostone / analysis Female Humans Leukotriene B4 / analysis Leukotriene E4 Male Maxillary Sinus / chemistry Middle Aged Mucous Membrane / chemistry Nasal Polyps / chemistry* Respiratory Hypersensitivity / metabolism Rhinitis / metabolism SRS-A / analogs & derivatives, analysis Thromboxane B2 / analysis |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/SRS-A; 363-24-6/Dinoprostone; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha; 71160-24-2/Leukotriene B4; 75715-89-8/Leukotriene E4 |
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