Document Detail


Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex.
MedLine Citation:
PMID:  2384159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mass spectral and chromatographic analysis demonstrates the presence of 14,15-, 11,12- and 8,9-epoxyeicosatrienoic acids (44%, 33% and 23% of the total, respectively) in human kidney cortex. Chiral analysis of the human renal epoxyeicosatrienoic acids shows the formation of 8,9-, 11,12- and 14,15-epoxyeicosatrienoic acids in a 1:1, 4:1 and 2:1 ratio of antipodes, respectively. These results demonstrate the biosynthetic origin of the human kidney 11,12- and 14,15-epoxyeicosatrienoic acids and suggest a role for renal cytochrome P-450 in the bioactivation of endogenous pools of arachidonic acid.
Authors:
A Karara; E Dishman; H Jacobson; J R Falck; J H Capdevila
Related Documents :
17970279 - Metabolism of arachidonic acid in sheep uterus: in vitro studies.
2510729 - Palmitoyl-l-carnitine increases the release of prostacyclin from vascular endothelial c...
2459909 - Clonal differences in prostaglandin synthesis among osteosarcoma cell lines.
6422509 - Effects of antioxidants on cyclooxygenase and lipoxygenase activities in intact human p...
1696009 - Direct modulation of secretory chloride channels by arachidonic and other cis unsaturat...
3096409 - The inflammatory response of rabbit skin to topical arachidonic acid and its pharmacolo...
10318669 - Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids ...
7668929 - Fatty acid and carotenoid composition of rhodotorula strains.
1903659 - Soybean lipoxygenase catalysed oxygenation of unsaturated fatty acid encapsulated in cy...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  FEBS letters     Volume:  268     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-09-20     Completed Date:  1990-09-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  227-30     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Vanderbilt University Medical School, Nashville, TN 37232.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
8,11,14-Eicosatrienoic Acid / analogs & derivatives,  analysis*
Cytochrome P-450 Enzyme System / metabolism*
Fatty Acids, Unsaturated / analysis*
Humans
Kidney Cortex / analysis*
Male
Mass Spectrometry
Oxygenases / metabolism*
Stereoisomerism
Grant Support
ID/Acronym/Agency:
DK38226/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 7324-41-6/8,11,14-Eicosatrienoic Acid; 81246-85-7/8,9-epoxyeicosatrienoic acid; 81276-02-0/11,12-epoxy-5,8,14-eicosatrienoic acid; 81276-03-1/14,15-epoxy-5,8,11-eicosatrienoic acid; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.13.-/Oxygenases; EC 1.14.14.1/arachidonate epoxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The apparent molecular size of native alpha-crystallin B in non-lenticular tissues.
Next Document:  Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes.