| Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex. | |
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MedLine Citation:
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PMID: 2384159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mass spectral and chromatographic analysis demonstrates the presence of 14,15-, 11,12- and 8,9-epoxyeicosatrienoic acids (44%, 33% and 23% of the total, respectively) in human kidney cortex. Chiral analysis of the human renal epoxyeicosatrienoic acids shows the formation of 8,9-, 11,12- and 14,15-epoxyeicosatrienoic acids in a 1:1, 4:1 and 2:1 ratio of antipodes, respectively. These results demonstrate the biosynthetic origin of the human kidney 11,12- and 14,15-epoxyeicosatrienoic acids and suggest a role for renal cytochrome P-450 in the bioactivation of endogenous pools of arachidonic acid. |
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Authors:
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A Karara; E Dishman; H Jacobson; J R Falck; J H Capdevila |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: FEBS letters Volume: 268 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1990-09-20 Completed Date: 1990-09-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 227-30 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Vanderbilt University Medical School, Nashville, TN 37232. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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8,11,14-Eicosatrienoic Acid
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analogs & derivatives,
analysis* Cytochrome P-450 Enzyme System / metabolism* Fatty Acids, Unsaturated / analysis* Humans Kidney Cortex / analysis* Male Mass Spectrometry Oxygenases / metabolism* Stereoisomerism |
| Grant Support | |
ID/Acronym/Agency:
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DK38226/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Unsaturated; 7324-41-6/8,11,14-Eicosatrienoic Acid; 81246-85-7/8,9-epoxyeicosatrienoic acid; 81276-02-0/11,12-epoxy-5,8,14-eicosatrienoic acid; 81276-03-1/14,15-epoxy-5,8,11-eicosatrienoic acid; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.13.-/Oxygenases; EC 1.14.14.1/arachidonate epoxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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