Document Detail


Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex.
MedLine Citation:
PMID:  2384159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mass spectral and chromatographic analysis demonstrates the presence of 14,15-, 11,12- and 8,9-epoxyeicosatrienoic acids (44%, 33% and 23% of the total, respectively) in human kidney cortex. Chiral analysis of the human renal epoxyeicosatrienoic acids shows the formation of 8,9-, 11,12- and 14,15-epoxyeicosatrienoic acids in a 1:1, 4:1 and 2:1 ratio of antipodes, respectively. These results demonstrate the biosynthetic origin of the human kidney 11,12- and 14,15-epoxyeicosatrienoic acids and suggest a role for renal cytochrome P-450 in the bioactivation of endogenous pools of arachidonic acid.
Authors:
A Karara; E Dishman; H Jacobson; J R Falck; J H Capdevila
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  FEBS letters     Volume:  268     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-09-20     Completed Date:  1990-09-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  227-30     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Vanderbilt University Medical School, Nashville, TN 37232.
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MeSH Terms
Descriptor/Qualifier:
8,11,14-Eicosatrienoic Acid / analogs & derivatives,  analysis*
Cytochrome P-450 Enzyme System / metabolism*
Fatty Acids, Unsaturated / analysis*
Humans
Kidney Cortex / analysis*
Male
Mass Spectrometry
Oxygenases / metabolism*
Stereoisomerism
Grant Support
ID/Acronym/Agency:
DK38226/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 7324-41-6/8,11,14-Eicosatrienoic Acid; 81246-85-7/8,9-epoxyeicosatrienoic acid; 81276-02-0/11,12-epoxy-5,8,14-eicosatrienoic acid; 81276-03-1/14,15-epoxy-5,8,11-eicosatrienoic acid; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.13.-/Oxygenases; EC 1.14.14.1/arachidonate epoxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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