Document Detail

Arachidonic acid and early human growth: is there a relation?
MedLine Citation:
PMID:  1952812     Owner:  NLM     Status:  MEDLINE    
Growth failure is a classical sign of essential fatty acid deficiency. We investigated whether birth weight correlates with the postnatal essential fatty acid status in a group of 29 premature infants. A significant and positive correlation between body weight and plasma triglyceride content of arachidonic acid (20:4n-6) (r = 0.47, p = 0.01) and total omega-6 long-chain polyunsaturated fatty acids (r = 0.49, p less than 0.01) was found. In contrast, there was no positive relation to linoleic acid (18:2n-6) or any omega-3 fatty acid but a significant inverse correlation to alpha-linolenic acid (18:3n-3). We propose that during early life arachidonic acid may have a growth-promoting effect which could be related to its role as an eicosanoid precursor or to its structural function in membrane lipids.
B Koletzko; M Braun
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  35     ISSN:  0250-6807     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  1991  
Date Detail:
Created Date:  1991-11-27     Completed Date:  1991-11-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  128-31     Citation Subset:  IM    
Kinderklinik, Heinrich-Heine-Universität, Düsseldorf, BRD.
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MeSH Terms
Arachidonic Acid / blood*
Birth Weight
Fatty Acids / blood,  metabolism
Fatty Acids, Omega-3 / blood
Growth / physiology*
Infant, Newborn
Infant, Premature
Linoleic Acids / blood
Lipids / blood
Regression Analysis
Triglycerides / blood
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Linoleic Acids; 0/Lipids; 0/Triglycerides; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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