Document Detail

Arachidonic acid content in adipose tissue is associated with insulin resistance in healthy children.
MedLine Citation:
PMID:  17204958     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The fatty acid composition of membrane structural lipids, which is partly dependent on dietary intake, is associated with insulin action. AIM: To examine the association between fatty acid composition of adipose tissue and skeletal muscle phospholipids with insulin resistance markers in a healthy pediatric population. METHODS: Using a cross-sectional design, we studied 83 healthy children divided into 3 groups, ages 2 to 5, 6 to 10 and more than 10 years. MEASUREMENTS: Fatty acid composition of adipose tissue triacylglycerols and skeletal muscle phospholipids, plasma lipid profile and fasting plasma levels of glucose and insulin were measured. RESULTS: There was a linear increase of insulinemia, glycemia and homeostasis adipose tissue model assessment (HOMA) index throughout the pediatric age range. Linoleic acid proportion in skeletal muscle and arachidonic acid proportion in adipose tissue also increased significantly with age. An age-independent positive correlation between insulinemia or HOMA index and arachidonic acid content in adipose tissue triacylglycerols (r = 0.47, P < 0.001) was found. An age-dependent negative correlation was present between insulinemia or HOMA index and oleic acid content in skeletal muscle phospholipids (r = -0.30, P = 0.03 and r = -0.28, P < 0.04, respectively). Trans fatty acids content did not correlate with any marker of insulin resistance. CONCLUSION: Healthy children present a prepubertal increase of insulin resistance, which is significantly correlated with arachidonic acid content in adipose tissue.
Luis Aldámiz-Echevarría; José A Prieto; Fernando Andrade; Javier Elorz; Pablo Sanjurjo; Juan Rodríguez Soriano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  44     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-05     Completed Date:  2007-02-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-83     Citation Subset:  IM    
Division of Metabolism, Department of Pediatrics, Cruces Hospital and Basque University School of Medicine, Bilbao, Spain.
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MeSH Terms
Adipose Tissue / chemistry*
Arachidonic Acid / analysis*
Biological Markers
Body Composition
Child, Preschool
Cross-Sectional Studies
Insulin Resistance / physiology*
Muscle, Skeletal / chemistry*
Phospholipids / chemistry
Triglycerides / chemistry
Reg. No./Substance:
0/Biological Markers; 0/Phospholipids; 0/Triglycerides; 506-32-1/Arachidonic Acid

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