| Arachidonic acid and arachidonoyl-diglycerols increase in rat cerebrum during bicuculline-induced status epilepticus. | |
| | |
MedLine Citation:
|
PMID: 6811964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Bicuculline-induced status epilepticus was found to be associated with increased amounts of free fatty acids and diacylglycerols in the rat cerebrum. The predominant fatty acid in both lipid pools was arachidonic acid. The accumulation of arachidonoyl-diglycerols decreased at the time of and during behavioral seizures induced by bicuculline, while the amount of free arachidonic acid appeared to increase. We propose a metabolic relationship between these lipids to explain the described changes. The similarities between the composition of the lipid pools and the fatty acid composition of phosphatidylinositol support the hypothesis that these changes may be a result of a convulsion-activated degradation of this phospholipid from excitable membranes. |
| | |
Authors:
|
N G Bazan; S A Morelli de Liberti; E B Rodriguez de Turco |
Related Documents
:
|
6129894 - Interaction of fatty acids with the calcium-magnesium ion dependent adenosinetriphospha... 10736004 - Influence of growth temperature on cryotolerance and lipid composition of lactobacillus... 18665464 - Temperature-dependent lipid levels and components in polar and temperate eelpout (zoarc... 699914 - Studies on lipid a from yersinia pseudotuberculosis lipopolysaccharide. isolation and g... 17263464 - Chemical changes and overexpressed genes in sweet basil (ocimum basilicum l.) upon meth... 9247224 - The protective role of gastric acidity in neonatal bacterial translocation. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Neurochemical research Volume: 7 ISSN: 0364-3190 ISO Abbreviation: Neurochem. Res. Publication Date: 1982 Jul |
Date Detail:
|
Created Date: 1982-12-02 Completed Date: 1982-12-02 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 839-43 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arachidonic Acid Arachidonic Acids / metabolism* Bicuculline / pharmacology* Cerebral Cortex / drug effects*, metabolism Diglycerides / metabolism* Fatty Acids / metabolism Glycerides / metabolism* Male Rats Rats, Inbred Strains Seizures / chemically induced*, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Arachidonic Acids; 0/Diglycerides; 0/Fatty Acids; 0/Glycerides; 485-49-4/Bicuculline; 506-32-1/Arachidonic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Glutamate dehydrogenase deficiency in spinocerebellar degenerations.
Next Document: Ventral root depolarization and spinal reflex augmentation by a TRH analog in rat spinal cord.