Document Detail

Arachidonic acid and arachidonoyl-diglycerols increase in rat cerebrum during bicuculline-induced status epilepticus.
MedLine Citation:
PMID:  6811964     Owner:  NLM     Status:  MEDLINE    
Bicuculline-induced status epilepticus was found to be associated with increased amounts of free fatty acids and diacylglycerols in the rat cerebrum. The predominant fatty acid in both lipid pools was arachidonic acid. The accumulation of arachidonoyl-diglycerols decreased at the time of and during behavioral seizures induced by bicuculline, while the amount of free arachidonic acid appeared to increase. We propose a metabolic relationship between these lipids to explain the described changes. The similarities between the composition of the lipid pools and the fatty acid composition of phosphatidylinositol support the hypothesis that these changes may be a result of a convulsion-activated degradation of this phospholipid from excitable membranes.
N G Bazan; S A Morelli de Liberti; E B Rodriguez de Turco
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurochemical research     Volume:  7     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  839-43     Citation Subset:  IM    
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MeSH Terms
Arachidonic Acid
Arachidonic Acids / metabolism*
Bicuculline / pharmacology*
Cerebral Cortex / drug effects*,  metabolism
Diglycerides / metabolism*
Fatty Acids / metabolism
Glycerides / metabolism*
Rats, Inbred Strains
Seizures / chemically induced*,  metabolism
Reg. No./Substance:
0/Arachidonic Acids; 0/Diglycerides; 0/Fatty Acids; 0/Glycerides; 485-49-4/Bicuculline; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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