Document Detail


Arachidonic acid and acetylcholine induced relaxation of bovine coronary artery: effect of indomethacin and methylene blue.
MedLine Citation:
PMID:  3087607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endothelial intact bovine coronary artery (BCA) rings precontracted with U46619 relax to acetylcholine (Ach) and arachidonic acid (AA). Relaxation to Ach is blocked by atropine. In an attempt to elucidate the mechanisms of these responses, we found that preincubation with methylene blue, an inhibitor of soluble guanylate cyclase activity, inhibited both Ach and AA induced relaxation. Preincubation with indomethacin had no effect on Ach induced relaxation, but partially inhibited the relaxation of endothelial intact BCA rings to AA.
Authors:
D G Guinee; D B McNamara; L J Ignarro; A L Hyman; P J Kadowitz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  2     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:    1986 May-Jun
Date Detail:
Created Date:  1986-08-12     Completed Date:  1986-08-12     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  170-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology*
Animals
Antioxidants / pharmacology
Arachidonic Acid
Arachidonic Acids / pharmacology*
Atropine / pharmacology
Catechols / pharmacology
Cattle
Coronary Vessels / drug effects*,  physiology
Indomethacin / pharmacology*
Methylene Blue / pharmacology*
Muscle Contraction / drug effects
Muscle, Smooth, Vascular / drug effects*,  physiology
Nordihydroguaiaretic Acid
Grant Support
ID/Acronym/Agency:
AM17692/AM/NIADDK NIH HHS; HL27713/HL/NHLBI NIH HHS; HL29456/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Arachidonic Acids; 0/Catechols; 500-38-9/Nordihydroguaiaretic Acid; 506-32-1/Arachidonic Acid; 51-55-8/Atropine; 51-84-3/Acetylcholine; 53-86-1/Indomethacin; 61-73-4/Methylene Blue

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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