| Arachidonic Acid：a Bridge between Traumatic Brain Injury and Fracture Healing. | |
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MedLine Citation:
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PMID: 22867040 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Traumatic brain injury (TBI) is associated with enhanced osteogenesis. The aim of this study was to investigate the effect of serum from TBI rats on fracture healing. Results from this study showed that the serum from TBI rats enhanced the expression of bone gamma carboxyglutamate protein (BGLAP) and promoted in vitro proliferation of MC3T3-E1 cells, a mouse osteoblastic cell line. Furthermore, gas chromatography/mass spectrometer (GC/MS) coupled with multivariate statistical analysis was used to identify the changes of global serum metabolites after TBI. We found the arachidonic acid (AA) was significantly enhanced in serum metabolites in TBI subjects, while hydroxybutyric acid, leucine, malic acid, 5-oxyproline, isocitric acid, mannose, and uric acid were reduced. Finally, we examined the effects of AA on BGLAP expression and cell proliferation in MC3T3-E1 cells. We found that BGLAP expression and proliferation of osteoblasts were positively regulated in the presence of AA. These findings suggest that the increased AA in serum after TBI may play a key role in enhancing the speed of fracture healing. |
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Authors:
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Shuguang Yang; Yanhong Ma; Yong Liu; Haiping Que; Changqiang Zhu; Shaojun Liu |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-6 |
Journal Detail:
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Title: Journal of neurotrauma Volume: - ISSN: 1557-9042 ISO Abbreviation: J. Neurotrauma Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8811626 Medline TA: J Neurotrauma Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute of Basic Medical Sciences, Department of Neurobiology, 27 Taiping road, Beijing, China, 100850; lionfmmu@yahoo.com.cn. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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