Document Detail

Arachidonate-induced experimental nerve infarction.
MedLine Citation:
PMID:  7229655     Owner:  NLM     Status:  MEDLINE    
Despite the clinical importance of ischemia in the pathogenesis of many human neuropathies, little is known about the effect of circulatory compromise on the structure of peripheral nerves. This results in part from the lack of an entirely satisfactory model in which to study ischemic neuropathy. We therefore injected arachidonic acid, a potent stimulus to platelet aggregation and vasoconstriction, into the femoral artery of normal rats. This resulted in the rapid onset of focal infarction of the proximal posterior tibial nerve in all animals. Distally there was evidence of Wallerian degeneration but not of primary ischemic damage. The site and nature of the infarct and the temporal sequence of the pathological changes were highly consistent. This new method is a simple and highly reproducible means of producing experimental nerve infarction.
G J Parry; M J Brown
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  50     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-07-09     Completed Date:  1981-07-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  123-33     Citation Subset:  IM    
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MeSH Terms
Arachidonic Acids / pharmacology*
Hindlimb / blood supply
Infarction / chemically induced*,  pathology
Platelet Aggregation / drug effects
Tibial Nerve / blood supply*,  pathology
Wallerian Degeneration / drug effects
Grant Support
Reg. No./Substance:
0/Arachidonic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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